Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

"Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex pathogenesis in which genetic, hormonal and environmental factors have a role. Rare mutations in the TREX1 gene, the major mammalian 3?-5? exonuclease, have been reported in sporadic SLE cases. Some of these...

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Autores Principales: Namjou B., Kothari P.H., Kelly J.A., Glenn S.B., Ojwang J.O., Adler A., Alarcón-Riquelme M.E., Gallant C.J., Boackle S.A., Criswell L.A., Kimberly R.P., Brown E., Edberg J., Stevens A.M., Jacob C.O., Tsao B.P., Gilkeson G.S., Kamen D.L., Merrill J.T., Petri M., Goldman R.R., Vila L.M., Anaya, Juan-Manuel, Niewold T.B., Martin J., Pons-Estel B.A., Sabio J.M., Callejas J.L., Vyse T.J., Bae S.-C., Perrino F.W., Freedman B.I., Scofield R.H., Moser K.L., Gaffney P.M., James J.A., Langefeld C.D., Kaufman K.M., Harley J.B., Atkinson J.P.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2011
Materias:
Sle
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24134
https://doi.org/10.1038/gene.2010.73