Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS)

"Maturation of type I sulfatases requires the conversion of the cysteine (Cys) or serine (Ser) present in the active site to formylglycine (FGly). This activation represents a limiting step during the production of recombinant sulfatases in bacteria and eukaryotic hosts. AslB, YdeM and YidF hav...

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Detalles Bibliográficos
Autores Principales: Alméciga-Díaz C.J., Tolosa-Díaz A.D., Pimentel L.N., Bonilla Y.A., Rodríguez-López A., Espejo-Mojica A.J., Patiño J.D., Sánchez O.F., Gonzalez-Santos J.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier B.V. 2017
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24133
https://doi.org/10.1016/j.gene.2017.08.043