Interaction between stress and addiction: Contributions from Latin-American neuroscience

"Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It...

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Autores Principales: Torres-Berrio, Angélica, Cuesta, Santiago, Nava-Mesa, Mauricio O., López Guzmán, Silvia
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Frontiers Media S.A. 2018
Materias:
CRF
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24101
https://doi.org/10.3389/fpsyg.2018.02639
id ir-10336-24101
recordtype dspace
spelling ir-10336-241012021-09-14T11:57:49Z Interaction between stress and addiction: Contributions from Latin-American neuroscience Torres-Berrio, Angélica Cuesta, Santiago Nava-Mesa, Mauricio O. López Guzmán, Silvia Addiction Biomarkers CRF Latin America Mesocorticolimbic pathway Stress "Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain's reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Indeed, the HPA axis, the autonomic nervous system, and the extended amygdala, among other brain stress systems, interact with the brain's reward circuit involved in addictive behaviors. There has been a growing interest in studying the molecular, cellular, and behavioral mechanisms of stress and addiction in Latin-America over the last decade. Nonetheless, these contributions may not be as strongly acknowledged by the broad scientific audience as studies coming from developed countries. In this review, we compile for the first time a series of studies conducted by Latin American-based neuroscientists, who have devoted their careers to studying the interaction between stress and addiction, from a neurobiological and clinical perspective. Specific contributions about this interaction include the study of CRF receptors in the lateral septum, investigations on the neural mechanisms of cross-sensitization for psychostimulants and ethanol, the identification of the Wnt/?-catenin pathway as a critical neural substrate for stress and addiction, and the emergence of the cannabinoid system as a promising therapeutic target. We highlight animal and human studies, including for instance, reports coming from Latin American laboratories on single nucleotide polymorphisms in stress-related genes and potential biomarkers of vulnerability to addiction, that aim to bridge the knowledge from basic science to clinical research. © 2018 Torres-Berrio, Cuesta, Lopez-Guzman and Nava-Mesa." 2018 2020-05-26T00:08:39Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 16641078 https://repository.urosario.edu.co/handle/10336/24101 https://doi.org/10.3389/fpsyg.2018.02639 eng info:eu-repo/semantics/openAccess application/pdf Frontiers Media S.A. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Addiction
Biomarkers
CRF
Latin America
Mesocorticolimbic pathway
Stress
spellingShingle Addiction
Biomarkers
CRF
Latin America
Mesocorticolimbic pathway
Stress
Torres-Berrio, Angélica
Cuesta, Santiago
Nava-Mesa, Mauricio O.
López Guzmán, Silvia
Interaction between stress and addiction: Contributions from Latin-American neuroscience
description "Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain's reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Indeed, the HPA axis, the autonomic nervous system, and the extended amygdala, among other brain stress systems, interact with the brain's reward circuit involved in addictive behaviors. There has been a growing interest in studying the molecular, cellular, and behavioral mechanisms of stress and addiction in Latin-America over the last decade. Nonetheless, these contributions may not be as strongly acknowledged by the broad scientific audience as studies coming from developed countries. In this review, we compile for the first time a series of studies conducted by Latin American-based neuroscientists, who have devoted their careers to studying the interaction between stress and addiction, from a neurobiological and clinical perspective. Specific contributions about this interaction include the study of CRF receptors in the lateral septum, investigations on the neural mechanisms of cross-sensitization for psychostimulants and ethanol, the identification of the Wnt/?-catenin pathway as a critical neural substrate for stress and addiction, and the emergence of the cannabinoid system as a promising therapeutic target. We highlight animal and human studies, including for instance, reports coming from Latin American laboratories on single nucleotide polymorphisms in stress-related genes and potential biomarkers of vulnerability to addiction, that aim to bridge the knowledge from basic science to clinical research. © 2018 Torres-Berrio, Cuesta, Lopez-Guzman and Nava-Mesa."
format Artículo (Article)
author Torres-Berrio, Angélica
Cuesta, Santiago
Nava-Mesa, Mauricio O.
López Guzmán, Silvia
author_facet Torres-Berrio, Angélica
Cuesta, Santiago
Nava-Mesa, Mauricio O.
López Guzmán, Silvia
author_sort Torres-Berrio, Angélica
title Interaction between stress and addiction: Contributions from Latin-American neuroscience
title_short Interaction between stress and addiction: Contributions from Latin-American neuroscience
title_full Interaction between stress and addiction: Contributions from Latin-American neuroscience
title_fullStr Interaction between stress and addiction: Contributions from Latin-American neuroscience
title_full_unstemmed Interaction between stress and addiction: Contributions from Latin-American neuroscience
title_sort interaction between stress and addiction: contributions from latin-american neuroscience
publisher Frontiers Media S.A.
publishDate 2018
url https://repository.urosario.edu.co/handle/10336/24101
https://doi.org/10.3389/fpsyg.2018.02639
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score 11,828437