%0 Artículo (Article) %A Muñoz, José Fernando %D 2013 %G Inglés (English) %T The eukaryotic genome, its reads, and the unfinished assembly %U https://repository.urosario.edu.co/handle/10336/24056 %U https://doi.org/10.1016/j.febslet.2013.05.048 %X In recent years, readily affordable short read sequences provided by next-generation sequencing (NGS) have become longer and more accurate. This has led to a jump in interest in the utility of NGS-only approaches for exploring eukaryotic genomes. The concept of a static, 'finished' genome assembly, which still appears to be a faraway goal for many eukaryotes, is yielding to new paradigms. We here motivate an object-view concept where the raw reads are the main, fixed object, and assemblies with their annotations take a role of dynamically changing and modifiable views of that object. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.