Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporo...
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ir-10336-240482022-05-02T12:37:21Z Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine Patarroyo, Manuel E Moreno-Vranich, Armando Bermudez, Adriana Apical merozoite antigen 1 Duffy binding like protein Erythrocyte membrane protein 1 Major histocompatibility antigen class 2 Malaria vaccine Merozoite surface protein Parasite antigen Rhoptry associated protein Serine repeat antigen 5 Sporozoite protein T lymphocyte receptor Unclassified drug Drug efficacy Drug synthesis Drug targeting Human Immunogenicity Malaria falciparum Merozoite Nonhuman Pathogenesis Plasmodium falciparum Plasmodium knowlesi Plasmodium vivax Priority journal Protein binding Review Sporozoite Drug discovery Humans Magnetic resonance spectroscopy Malaria vaccines Plasmodium falciparum Protein conformation Fully protective Subunit-based Synthetic antimalaria vaccine subunit falciparum Malaria Vaccines If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd. 2012 2020-05-26T00:08:01Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14760584 https://repository.urosario.edu.co/handle/10336/24048 https://doi.org/10.1586/erv.12.57 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Apical merozoite antigen 1 Duffy binding like protein Erythrocyte membrane protein 1 Major histocompatibility antigen class 2 Malaria vaccine Merozoite surface protein Parasite antigen Rhoptry associated protein Serine repeat antigen 5 Sporozoite protein T lymphocyte receptor Unclassified drug Drug efficacy Drug synthesis Drug targeting Human Immunogenicity Malaria falciparum Merozoite Nonhuman Pathogenesis Plasmodium falciparum Plasmodium knowlesi Plasmodium vivax Priority journal Protein binding Review Sporozoite Drug discovery Humans Magnetic resonance spectroscopy Malaria vaccines Plasmodium falciparum Protein conformation Fully protective Subunit-based Synthetic antimalaria vaccine subunit falciparum Malaria Vaccines |
spellingShingle |
Apical merozoite antigen 1 Duffy binding like protein Erythrocyte membrane protein 1 Major histocompatibility antigen class 2 Malaria vaccine Merozoite surface protein Parasite antigen Rhoptry associated protein Serine repeat antigen 5 Sporozoite protein T lymphocyte receptor Unclassified drug Drug efficacy Drug synthesis Drug targeting Human Immunogenicity Malaria falciparum Merozoite Nonhuman Pathogenesis Plasmodium falciparum Plasmodium knowlesi Plasmodium vivax Priority journal Protein binding Review Sporozoite Drug discovery Humans Magnetic resonance spectroscopy Malaria vaccines Plasmodium falciparum Protein conformation Fully protective Subunit-based Synthetic antimalaria vaccine subunit falciparum Malaria Vaccines Patarroyo, Manuel E Moreno-Vranich, Armando Bermudez, Adriana Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
description |
If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd. |
format |
Artículo (Article) |
author |
Patarroyo, Manuel E Moreno-Vranich, Armando Bermudez, Adriana |
author_facet |
Patarroyo, Manuel E Moreno-Vranich, Armando Bermudez, Adriana |
author_sort |
Patarroyo, Manuel E |
title |
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
title_short |
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
title_full |
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
title_fullStr |
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
title_full_unstemmed |
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine |
title_sort |
towards the development of a fully protective plasmodium falciparum antimalarial vaccine |
publishDate |
2012 |
url |
https://repository.urosario.edu.co/handle/10336/24048 https://doi.org/10.1586/erv.12.57 |
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1740172918295363584 |
score |
12,131701 |