Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine

If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporo...

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Autores Principales: Patarroyo, Manuel E, Moreno-Vranich, Armando, Bermudez, Adriana
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24048
https://doi.org/10.1586/erv.12.57
id ir-10336-24048
recordtype dspace
spelling ir-10336-240482022-05-02T12:37:21Z Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine Patarroyo, Manuel E Moreno-Vranich, Armando Bermudez, Adriana Apical merozoite antigen 1 Duffy binding like protein Erythrocyte membrane protein 1 Major histocompatibility antigen class 2 Malaria vaccine Merozoite surface protein Parasite antigen Rhoptry associated protein Serine repeat antigen 5 Sporozoite protein T lymphocyte receptor Unclassified drug Drug efficacy Drug synthesis Drug targeting Human Immunogenicity Malaria falciparum Merozoite Nonhuman Pathogenesis Plasmodium falciparum Plasmodium knowlesi Plasmodium vivax Priority journal Protein binding Review Sporozoite Drug discovery Humans Magnetic resonance spectroscopy Malaria vaccines Plasmodium falciparum Protein conformation Fully protective Subunit-based Synthetic antimalaria vaccine subunit falciparum Malaria Vaccines If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd. 2012 2020-05-26T00:08:01Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14760584 https://repository.urosario.edu.co/handle/10336/24048 https://doi.org/10.1586/erv.12.57 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Apical merozoite antigen 1
Duffy binding like protein
Erythrocyte membrane protein 1
Major histocompatibility antigen class 2
Malaria vaccine
Merozoite surface protein
Parasite antigen
Rhoptry associated protein
Serine repeat antigen 5
Sporozoite protein
T lymphocyte receptor
Unclassified drug
Drug efficacy
Drug synthesis
Drug targeting
Human
Immunogenicity
Malaria falciparum
Merozoite
Nonhuman
Pathogenesis
Plasmodium falciparum
Plasmodium knowlesi
Plasmodium vivax
Priority journal
Protein binding
Review
Sporozoite
Drug discovery
Humans
Magnetic resonance spectroscopy
Malaria vaccines
Plasmodium falciparum
Protein conformation
Fully protective
Subunit-based
Synthetic antimalaria vaccine
subunit
falciparum
Malaria
Vaccines
spellingShingle Apical merozoite antigen 1
Duffy binding like protein
Erythrocyte membrane protein 1
Major histocompatibility antigen class 2
Malaria vaccine
Merozoite surface protein
Parasite antigen
Rhoptry associated protein
Serine repeat antigen 5
Sporozoite protein
T lymphocyte receptor
Unclassified drug
Drug efficacy
Drug synthesis
Drug targeting
Human
Immunogenicity
Malaria falciparum
Merozoite
Nonhuman
Pathogenesis
Plasmodium falciparum
Plasmodium knowlesi
Plasmodium vivax
Priority journal
Protein binding
Review
Sporozoite
Drug discovery
Humans
Magnetic resonance spectroscopy
Malaria vaccines
Plasmodium falciparum
Protein conformation
Fully protective
Subunit-based
Synthetic antimalaria vaccine
subunit
falciparum
Malaria
Vaccines
Patarroyo, Manuel E
Moreno-Vranich, Armando
Bermudez, Adriana
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
description If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd.
format Artículo (Article)
author Patarroyo, Manuel E
Moreno-Vranich, Armando
Bermudez, Adriana
author_facet Patarroyo, Manuel E
Moreno-Vranich, Armando
Bermudez, Adriana
author_sort Patarroyo, Manuel E
title Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
title_short Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
title_full Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
title_fullStr Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
title_full_unstemmed Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
title_sort towards the development of a fully protective plasmodium falciparum antimalarial vaccine
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/24048
https://doi.org/10.1586/erv.12.57
_version_ 1740172918295363584
score 12,131701