Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides th...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24037 https://doi.org/10.1016/j.exppara.2006.02.005 |
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ir-10336-240372022-05-02T12:37:21Z Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model Siachoque H. Guzman F. Burgos J. Patarroyo M.E. Gomez Marin J.E. Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines surface animal inbred c3h protozoan protozoan secondary Antibodies Antigens Antigens Immunization Mice Toxoplasmosis Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved. 2006 2020-05-26T00:07:52Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 00144894 10902449 https://repository.urosario.edu.co/handle/10336/24037 https://doi.org/10.1016/j.exppara.2006.02.005 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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language |
Inglés (English) |
topic |
Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines surface animal inbred c3h protozoan protozoan secondary Antibodies Antigens Antigens Immunization Mice Toxoplasmosis |
spellingShingle |
Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines surface animal inbred c3h protozoan protozoan secondary Antibodies Antigens Antigens Immunization Mice Toxoplasmosis Siachoque H. Guzman F. Burgos J. Patarroyo M.E. Gomez Marin J.E. Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
description |
Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved. |
format |
Artículo (Article) |
author |
Siachoque H. Guzman F. Burgos J. Patarroyo M.E. Gomez Marin J.E. |
author_facet |
Siachoque H. Guzman F. Burgos J. Patarroyo M.E. Gomez Marin J.E. |
author_sort |
Siachoque H. |
title |
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
title_short |
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
title_full |
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
title_fullStr |
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
title_full_unstemmed |
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model |
title_sort |
toxoplasma gondii: immunogenicity and protection by p30 peptides in a murine model |
publishDate |
2006 |
url |
https://repository.urosario.edu.co/handle/10336/24037 https://doi.org/10.1016/j.exppara.2006.02.005 |
_version_ |
1740172335750578176 |
score |
12,131701 |