Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model

Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides th...

Descripción completa

Detalles Bibliográficos
Autores Principales: Siachoque H., Guzman F., Burgos J., Patarroyo M.E., Gomez Marin J.E.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2006
Materias:
P30
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24037
https://doi.org/10.1016/j.exppara.2006.02.005
Descripción
Sumario:Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved.