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Effect of low doses of estradiol and tamoxifen on breast cancer cell karyotypes

Evidence supports a role of 17?-estradiol (E2) in carcinogenesis and the large majority of breast carcinomas are dependent on estrogen. The anti-estrogen tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer; however, it is also carcinogenic in human uterus and rat liver,...

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Detalles Bibliográficos
Autores Principales: Rondón-Lagos, Milena, Rangel, Nelson, Di Cantogno, Ludovica Verdun, Annaratone, Laura, Castellano, Isabella, Russo, Rosalia, Manetta, Tilde, Marchiò, Caterina, Sapino, Anna
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: BioScientifica Ltd. 2016
Materias:
Epidermal growth factor receptor 2
Estradiol
Estrogen receptor
Progesterone receptor
Tamoxifen
Antiestrogen
Antineoplastic hormone agonists and antagonists
Article
Breast cancer cell line
Cell proliferation
Chromosome aberration
Chromosome rearrangement
Controlled study
Genotoxicity
Human
Human cell
In vitro study
Karyotype
Karyotyping
Low drug dose
Mcf 7 cell line
Treatment duration
Breast tumor
Chemically induced
Drug effects
Genetics
Tumor cell line
Breast neoplasms
Chromosome aberrations
Estrogen antagonists
Humans
Breast cancer cells
Chromosomal abnormalities
Chromosomal instability
tumor
hormonal
Antineoplastic agents
Cell line
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23922
https://doi.org/10.1530/ERC-16-0078

Internet

https://repository.urosario.edu.co/handle/10336/23922
https://doi.org/10.1530/ERC-16-0078

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