Mayaro: an emerging viral threat?
Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV). The term “ChikDenMaZika syndrome” has been coined for clinically suspected arboviruses,...
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ir-10336-239162022-05-02T12:37:16Z Mayaro: an emerging viral threat? Acosta-Ampudia, Yeny Monsalve, Diana M. Pacheco Nieva, Yovana Rodríguez, Yhojan Anaya, Juan-Manuel Ramirez-Santana, Carolina Alphavirus Arbovirus Arthralgia Bleeding Chikungunya virus Cross reaction Dengue virus Fever Genomics Human Life threat Maculopapular rash Mayaro virus Mixed infection Myocarditis Neurological complication Nonhuman Polyarthritis Priority journal Review South America Togaviridae Virus load Virus morphology Zika virus Alphavirus infection Animal Classification Communicable disease Genetics Isolation and purification Physiology Virology Alphavirus Alphavirus Infections Animals Humans South America Emerging Communicable Diseases Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV). The term “ChikDenMaZika syndrome” has been coined for clinically suspected arboviruses, which have arisen as a consequence of the high viral burden, viral co-infection, and co-circulation in South America. In most cases, MAYV disease is nonspecific, mild, and self-limited. Fever, arthralgia, and maculopapular rash are among the most common symptoms described, being largely indistinguishable from those caused by other arboviruses. However, severe manifestations of the infection have been reported, such as chronic polyarthritis, neurological complications, hemorrhage, myocarditis, and even death. Currently, there are no specific commercial tools for the diagnosis of MAYV, and the use of serological methods can be affected by cross-reactivity and the window period. A diagnosis based on clinical and epidemiological data alone is still premature. Therefore, new entomological research is warranted, and new highly specific molecular diagnostic methods should be developed. This comprehensive review is intended to encourage public health authorities and scientific communities to actively work on diagnosing, preventing, and treating MAYV infection. © 2018, The Author(s). 2018 2020-05-26T00:06:39Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 22221751 https://repository.urosario.edu.co/handle/10336/23916 https://doi.org/10.1038/s41426-018-0163-5 eng info:eu-repo/semantics/openAccess application/pdf Nature Publishing Group instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Alphavirus Arbovirus Arthralgia Bleeding Chikungunya virus Cross reaction Dengue virus Fever Genomics Human Life threat Maculopapular rash Mayaro virus Mixed infection Myocarditis Neurological complication Nonhuman Polyarthritis Priority journal Review South America Togaviridae Virus load Virus morphology Zika virus Alphavirus infection Animal Classification Communicable disease Genetics Isolation and purification Physiology Virology Alphavirus Alphavirus Infections Animals Humans South America Emerging Communicable Diseases |
spellingShingle |
Alphavirus Arbovirus Arthralgia Bleeding Chikungunya virus Cross reaction Dengue virus Fever Genomics Human Life threat Maculopapular rash Mayaro virus Mixed infection Myocarditis Neurological complication Nonhuman Polyarthritis Priority journal Review South America Togaviridae Virus load Virus morphology Zika virus Alphavirus infection Animal Classification Communicable disease Genetics Isolation and purification Physiology Virology Alphavirus Alphavirus Infections Animals Humans South America Emerging Communicable Diseases Acosta-Ampudia, Yeny Monsalve, Diana M. Pacheco Nieva, Yovana Rodríguez, Yhojan Anaya, Juan-Manuel Ramirez-Santana, Carolina Mayaro: an emerging viral threat? |
description |
Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV). The term “ChikDenMaZika syndrome” has been coined for clinically suspected arboviruses, which have arisen as a consequence of the high viral burden, viral co-infection, and co-circulation in South America. In most cases, MAYV disease is nonspecific, mild, and self-limited. Fever, arthralgia, and maculopapular rash are among the most common symptoms described, being largely indistinguishable from those caused by other arboviruses. However, severe manifestations of the infection have been reported, such as chronic polyarthritis, neurological complications, hemorrhage, myocarditis, and even death. Currently, there are no specific commercial tools for the diagnosis of MAYV, and the use of serological methods can be affected by cross-reactivity and the window period. A diagnosis based on clinical and epidemiological data alone is still premature. Therefore, new entomological research is warranted, and new highly specific molecular diagnostic methods should be developed. This comprehensive review is intended to encourage public health authorities and scientific communities to actively work on diagnosing, preventing, and treating MAYV infection. © 2018, The Author(s). |
format |
Artículo (Article) |
author |
Acosta-Ampudia, Yeny Monsalve, Diana M. Pacheco Nieva, Yovana Rodríguez, Yhojan Anaya, Juan-Manuel Ramirez-Santana, Carolina |
author_facet |
Acosta-Ampudia, Yeny Monsalve, Diana M. Pacheco Nieva, Yovana Rodríguez, Yhojan Anaya, Juan-Manuel Ramirez-Santana, Carolina |
author_sort |
Acosta-Ampudia, Yeny |
title |
Mayaro: an emerging viral threat? |
title_short |
Mayaro: an emerging viral threat? |
title_full |
Mayaro: an emerging viral threat? |
title_fullStr |
Mayaro: an emerging viral threat? |
title_full_unstemmed |
Mayaro: an emerging viral threat? |
title_sort |
mayaro: an emerging viral threat? |
publisher |
Nature Publishing Group |
publishDate |
2018 |
url |
https://repository.urosario.edu.co/handle/10336/23916 https://doi.org/10.1038/s41426-018-0163-5 |
_version_ |
1740172563062980608 |
score |
12,131701 |