Vista Equipo: The impact of HIV-1 within-host evolution on transmission dynamics

The impact of HIV-1 within-host evolution on transmission dynamics

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within...

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Autores Principales:	Theys, Kristof, Libin, Pieter, Pineda-Peña, Andrea-Clemencia, Nowé, Ann, Vandamme, Anne-Mieke, Abecasis, Ana B
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	Elsevier B.V. 2018
Materias:	Chemokine receptor CCR5 Chemokine receptor CXCR4 Bottleneck population CD4 lymphocyte count Disease course Genetic distance Genetic variability Host pathogen interaction Human Human immunodeficiency virus 1 Molecular epidemiology Molecular evolution Nonhuman Phylogeny Priority journal Review Viral genetics Virus load Virus morphology Virus transmission Virus virulence Epidemic Genetics Human immunodeficiency virus infection Pathogenicity Theoretical model Transmission Virulence Epidemics HIV Infections HIV-1 Host-Pathogen Interactions Humans Theoretical Molecular Evolution Models
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/23826 https://doi.org/10.1016/j.coviro.2017.12.001

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recordtype	dspace
spelling	ir-10336-238262022-05-02T12:37:21Z The impact of HIV-1 within-host evolution on transmission dynamics Theys, Kristof Libin, Pieter Pineda-Peña, Andrea-Clemencia Nowé, Ann Vandamme, Anne-Mieke Abecasis, Ana B Chemokine receptor CCR5 Chemokine receptor CXCR4 Bottleneck population CD4 lymphocyte count Disease course Genetic distance Genetic variability Host pathogen interaction Human Human immunodeficiency virus 1 Molecular epidemiology Molecular evolution Nonhuman Phylogeny Priority journal Review Viral genetics Virus load Virus morphology Virus transmission Virus virulence Epidemic Genetics Host pathogen interaction Human immunodeficiency virus 1 Human immunodeficiency virus infection Molecular evolution Pathogenicity Theoretical model Transmission Virulence Epidemics HIV Infections HIV-1 Host-Pathogen Interactions Humans Virulence Theoretical Molecular Evolution Models The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission. © 2017 Elsevier B.V. 2018 2020-05-26T00:05:47Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 18796257 https://repository.urosario.edu.co/handle/10336/23826 https://doi.org/10.1016/j.coviro.2017.12.001 eng info:eu-repo/semantics/openAccess application/pdf Elsevier B.V. instname:Universidad del Rosario
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Inglés (English)
topic	Chemokine receptor CCR5 Chemokine receptor CXCR4 Bottleneck population CD4 lymphocyte count Disease course Genetic distance Genetic variability Host pathogen interaction Human Human immunodeficiency virus 1 Molecular epidemiology Molecular evolution Nonhuman Phylogeny Priority journal Review Viral genetics Virus load Virus morphology Virus transmission Virus virulence Epidemic Genetics Host pathogen interaction Human immunodeficiency virus 1 Human immunodeficiency virus infection Molecular evolution Pathogenicity Theoretical model Transmission Virulence Epidemics HIV Infections HIV-1 Host-Pathogen Interactions Humans Virulence Theoretical Molecular Evolution Models
spellingShingle	Chemokine receptor CCR5 Chemokine receptor CXCR4 Bottleneck population CD4 lymphocyte count Disease course Genetic distance Genetic variability Host pathogen interaction Human Human immunodeficiency virus 1 Molecular epidemiology Molecular evolution Nonhuman Phylogeny Priority journal Review Viral genetics Virus load Virus morphology Virus transmission Virus virulence Epidemic Genetics Host pathogen interaction Human immunodeficiency virus 1 Human immunodeficiency virus infection Molecular evolution Pathogenicity Theoretical model Transmission Virulence Epidemics HIV Infections HIV-1 Host-Pathogen Interactions Humans Virulence Theoretical Molecular Evolution Models Theys, Kristof Libin, Pieter Pineda-Peña, Andrea-Clemencia Nowé, Ann Vandamme, Anne-Mieke Abecasis, Ana B The impact of HIV-1 within-host evolution on transmission dynamics
description	The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission. © 2017 Elsevier B.V.
format	Artículo (Article)
author	Theys, Kristof Libin, Pieter Pineda-Peña, Andrea-Clemencia Nowé, Ann Vandamme, Anne-Mieke Abecasis, Ana B
author_facet	Theys, Kristof Libin, Pieter Pineda-Peña, Andrea-Clemencia Nowé, Ann Vandamme, Anne-Mieke Abecasis, Ana B
author_sort	Theys, Kristof
title	The impact of HIV-1 within-host evolution on transmission dynamics
title_short	The impact of HIV-1 within-host evolution on transmission dynamics
title_full	The impact of HIV-1 within-host evolution on transmission dynamics
title_fullStr	The impact of HIV-1 within-host evolution on transmission dynamics
title_full_unstemmed	The impact of HIV-1 within-host evolution on transmission dynamics
title_sort	impact of hiv-1 within-host evolution on transmission dynamics
publisher	Elsevier B.V.
publishDate	2018
url	https://repository.urosario.edu.co/handle/10336/23826 https://doi.org/10.1016/j.coviro.2017.12.001
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score	12,131701

The impact of HIV-1 within-host evolution on transmission dynamics

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