Infections and vaccines in the etiology of antiphospholipid syndrome
Purpose of review: To present scientific evidence supporting the infectious origin for the antiphospholipid syndrome (APS) by molecular mimicry between pathogens, infection and vaccination with ?2-glycoprotein I (?2-GPI) molecule. Recent findings: APS is characterized by the presence of pathogenic a...
Autores Principales: | , , , |
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Formato: | Artículo (Article) |
Lenguaje: | Inglés (English) |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23823 https://doi.org/10.1097/BOR.0b013e32835448b8 |
Sumario: | Purpose of review: To present scientific evidence supporting the infectious origin for the antiphospholipid syndrome (APS) by molecular mimicry between pathogens, infection and vaccination with ?2-glycoprotein I (?2-GPI) molecule. Recent findings: APS is characterized by the presence of pathogenic autoantibodies against ?2-GPI. The infection etiology of APS was well established. Likewise, a link between vaccination such as tetanus toxoid may trigger antibodies targeting tetanus toxoid and ?2-GPI, due to molecular mimicry between the two molecules. During the years, the pathogenic potential of anti-tetanus toxoid antibodies cross reactive with ?2-GPI were found to be pathogenic in animal models, inducing experimental APS. Summary: Accumulated evidence supports that the presence of anti-?2-GPI antibodies is associated with a history of infections and the main mechanism to explain this correlation is molecular mimicry. The relationship between tetanus toxoid vaccination and APS reveals a novel view on the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). © 2012 Wolters Kluwer Health |
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