Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia

Background: Breast cancer is highly prevalent worldwide and leads to high health-care costs. HER2-positive subtype represents 30% of all breast cancers and is associated with a poor prognosis. Patients treated with anti-HER2 therapies frequently develop resistance and require pharmacological treatme...

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Autores Principales: Sánchez-Calderón, Diana, Pedraza, Adriana, Mancera Urrego, Catalina, Mejía-Mejía, Aurelio, Montealegre-Páez, Ana Lorena, Perdomo, Sandra
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Dove Medical Press Ltd 2020
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23699
https://doi.org/10.2147/CEOR.S220726
id ir-10336-23699
recordtype dspace
spelling ir-10336-236992022-05-02T12:37:21Z Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia Sánchez-Calderón, Diana Pedraza, Adriana Mancera Urrego, Catalina Mejía-Mejía, Aurelio Montealegre-Páez, Ana Lorena Perdomo, Sandra Circulating tumor DNA Docetaxel Pertuzumab Trastuzumab Advanced cancer Cancer chemotherapy Cancer resistance Colombia Cost effectiveness analysis DNA determination Health care cost Human Human epidermal growth factor receptor 2 positive breast cancer Liquid biopsy Quality adjusted life year Review Sensitivity and specificity Treatment outcome Biomarkers Breast cancer Cost-effectiveness Liquid biopsy Background: Breast cancer is highly prevalent worldwide and leads to high health-care costs. HER2-positive subtype represents 30% of all breast cancers and is associated with a poor prognosis. Patients treated with anti-HER2 therapies frequently develop resistance and require pharmacological treatment change. Liquid biopsy is a minimally invasive and an easily accessible technique, with high sensitivity and specificity, to detect molecular treatment resistance even before the onset of clinical manifestations and can thus be used to reduce unnecessary anti-HER2 treatment costs. Objective: To evaluate the cost-effectiveness of using liquid biopsy (ctDNA detection) to determine treatment change in women with HER2-positive advanced breast cancer in Colombia. Methodology: We performed an economic evaluation using decision tree modeling and deterministic analyses based on literature search for first and second lines of treatment (trastuzumab, pertuzumab, docetaxel, and TDM1); resistance; outcomes; and sensitivity and specificity of tests detecting molecular resistance. The effectiveness was measured using quality-adjusted life year (QALY) score, and costs were obtained from databases with national validity, suppliers, the Colombian Drug Price Information System (SISMED), and local studies. Results: The use of liquid biopsy (ctDNA detection) with conventional treatment was more expensive and less effective than conventional treatment without liquid biopsy (US $177,985.35 and 0.533889206 QALY, respectively). The incremental cost with liquid biopsy was US $7,333.17 and the incremental effectiveness was 0.00042256 QALY relative to the conventional method. Conclusion: Including liquid biopsy in the treatment of HER2-positive advanced breast cancer was considered currently inapplicable in Colombia because it was not cost effective. Our results open a window of opportunity to improve the development and implementation of ctDNA testing in Colombia, potentially reducing current costs. More evidence is required on the utility of this test, depending on the financial capacity of Colombia and other countries. © 2020 Sánchez-Calderón et al. 2020 2020-05-26T00:04:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 11786981 https://repository.urosario.edu.co/handle/10336/23699 https://doi.org/10.2147/CEOR.S220726 eng info:eu-repo/semantics/openAccess application/pdf Dove Medical Press Ltd instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Circulating tumor DNA
Docetaxel
Pertuzumab
Trastuzumab
Advanced cancer
Cancer chemotherapy
Cancer resistance
Colombia
Cost effectiveness analysis
DNA determination
Health care cost
Human
Human epidermal growth factor receptor 2 positive breast cancer
Liquid biopsy
Quality adjusted life year
Review
Sensitivity and specificity
Treatment outcome
Biomarkers
Breast cancer
Cost-effectiveness
Liquid biopsy
spellingShingle Circulating tumor DNA
Docetaxel
Pertuzumab
Trastuzumab
Advanced cancer
Cancer chemotherapy
Cancer resistance
Colombia
Cost effectiveness analysis
DNA determination
Health care cost
Human
Human epidermal growth factor receptor 2 positive breast cancer
Liquid biopsy
Quality adjusted life year
Review
Sensitivity and specificity
Treatment outcome
Biomarkers
Breast cancer
Cost-effectiveness
Liquid biopsy
Sánchez-Calderón, Diana
Pedraza, Adriana
Mancera Urrego, Catalina
Mejía-Mejía, Aurelio
Montealegre-Páez, Ana Lorena
Perdomo, Sandra
Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
description Background: Breast cancer is highly prevalent worldwide and leads to high health-care costs. HER2-positive subtype represents 30% of all breast cancers and is associated with a poor prognosis. Patients treated with anti-HER2 therapies frequently develop resistance and require pharmacological treatment change. Liquid biopsy is a minimally invasive and an easily accessible technique, with high sensitivity and specificity, to detect molecular treatment resistance even before the onset of clinical manifestations and can thus be used to reduce unnecessary anti-HER2 treatment costs. Objective: To evaluate the cost-effectiveness of using liquid biopsy (ctDNA detection) to determine treatment change in women with HER2-positive advanced breast cancer in Colombia. Methodology: We performed an economic evaluation using decision tree modeling and deterministic analyses based on literature search for first and second lines of treatment (trastuzumab, pertuzumab, docetaxel, and TDM1); resistance; outcomes; and sensitivity and specificity of tests detecting molecular resistance. The effectiveness was measured using quality-adjusted life year (QALY) score, and costs were obtained from databases with national validity, suppliers, the Colombian Drug Price Information System (SISMED), and local studies. Results: The use of liquid biopsy (ctDNA detection) with conventional treatment was more expensive and less effective than conventional treatment without liquid biopsy (US $177,985.35 and 0.533889206 QALY, respectively). The incremental cost with liquid biopsy was US $7,333.17 and the incremental effectiveness was 0.00042256 QALY relative to the conventional method. Conclusion: Including liquid biopsy in the treatment of HER2-positive advanced breast cancer was considered currently inapplicable in Colombia because it was not cost effective. Our results open a window of opportunity to improve the development and implementation of ctDNA testing in Colombia, potentially reducing current costs. More evidence is required on the utility of this test, depending on the financial capacity of Colombia and other countries. © 2020 Sánchez-Calderón et al.
format Artículo (Article)
author Sánchez-Calderón, Diana
Pedraza, Adriana
Mancera Urrego, Catalina
Mejía-Mejía, Aurelio
Montealegre-Páez, Ana Lorena
Perdomo, Sandra
author_facet Sánchez-Calderón, Diana
Pedraza, Adriana
Mancera Urrego, Catalina
Mejía-Mejía, Aurelio
Montealegre-Páez, Ana Lorena
Perdomo, Sandra
author_sort Sánchez-Calderón, Diana
title Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
title_short Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
title_full Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
title_fullStr Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
title_full_unstemmed Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in Colombia
title_sort analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with her2-positive advanced breast cancer in colombia
publisher Dove Medical Press Ltd
publishDate 2020
url https://repository.urosario.edu.co/handle/10336/23699
https://doi.org/10.2147/CEOR.S220726
_version_ 1740172832042647552
score 12,131701