Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

"We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the o...

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Detalles Bibliográficos
Autores Principales: Caceres, Diego H., Scheel, Christina M., Tobón, Ángela M., Cleveland, Angela Ahlquist, Restrepo, Ángela, Brandt, Mary E., Chiller, Tom, Gómez, Beatriz L.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2014
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23675
https://doi.org/10.1128/CVI.00101-14
Descripción
Sumario:"We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy. Copyright © 2014, American Society for Microbiology. All Rights Reserved."