The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic

Objective The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious a...

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Autores Principales: Agmon-Levin N., Dagan A., Peri Y., Anaya, Juan-Manuel, Selmi C., Tincani A., Bizzaro N., Stojanovich L., Damoiseaux J., Tervaert J.W.C., Mosca M., Cervera R., Shoenfeld Y.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Clinical and Experimental Rheumatology S.A.S. 2017
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/23672
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spelling ir-10336-236722022-05-02T12:37:13Z The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic Agmon-Levin N. Dagan A. Peri Y. Anaya, Juan-Manuel Selmi C. Tincani A. Bizzaro N. Stojanovich L. Damoiseaux J. Tervaert J.W.C. Mosca M. Cervera R. Shoenfeld Y. Early antigen Immunoglobulin g antibody Immunoglobulin m antibody La antibody Ro antibody Antinuclear antibody Autoantibody Autoantigen Protozoon antibody Ribonucleoprotein Ss-a antibodies Ss-b antigen Virus antibody Anca associated vasculitis Antibody titer Antiphospholipid syndrome Article Autoimmune disease Autoimmune thyroiditis Celiac disease Cohort analysis Controlled study Cross-sectional study Cryoglobulinemia Cytomegalovirus Epstein barr virus Geography Giant cell arteritis Hepatitis c Human Immunoassay Inflammatory bowel disease Major clinical study Polymyositis Prevalence Primary biliary cirrhosis Priority journal Protein protein interaction Rheumatoid arthritis Sjoegren syndrome Systemic lupus erythematosus Systemic sclerosis Toxoplasma Wegener granulomatosis Autoimmune disease Biliary cirrhosis Blood Immunology Antiphospholipid syndrome Autoantibodies Autoantigens Autoimmune diseases Cohort studies Cross-sectional studies Cytomegalovirus Humans Ribonucleoproteins Sjogren's syndrome Toxoplasma Anti-la/ssb antibody Anti-ro/ssa antibody Antiphospholipid syndrome Autoimmunity Sjögren's syndrome Systemic lupus erythematosus systemic antinuclear viral biliary human protozoan Antibodies Antibodies Antibodies Herpesvirus 4 Liver cirrhosis Lupus erythematosus Objective The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies Methods We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. All samples were also tested for a variety of anti-infectious agents' antibodies using the BioPlex 2200-immunoassay (Bio-Rad, USA). Results Anti-Ro/SSA was more prevalent, with significantly higher titre in 5 autoimmune diseases namely Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) both primary and APS linked to SLE, systemic sclerosis (SSc) and primary biliary cirrhosis (PBC). Anti-La/SSB was more prevalent with higher titers in SS, SLE, APS linked to SLE and PBC. Prevalence, but not titers, of both antibodies were higher also in polymyositis (PM). Additionally, we found a correlation between anti-Ro/SSA antibodies and antibodies of the IgM and IgG subtypes directed at cytomegalovirus as well as IgG-antibodies directed at Epstein-Barr virus (EBV) and toxoplasma (p less than 0.001). Anti-La/SSB antibodies correlated with the presence of IgG antibodies against EBV early antigen (p less than 0.001). Conclusion In a large cohort of patients with autoimmune diseases we found an association between anti-Ro/SSA and anti-La/SSB antibodies and 6 autoimmune diseases, amongst which primary APS and PM. Additionally, we observed linkages between these autoantibodies and anti-infectious antibodies directed at Epstein-Barr virus, toxoplasma and cytomegalovirus. Our findings support the concept of interplay between infectious agents and autoimmunity, such as the plausibility of an infectious agent that trigger the immune system to produce specific antibodies which will later result in a unique group of AID. © Clinical and Experimental Rheumatology 2017. 2017 2020-05-26T00:04:17Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0392856X 1593098X https://repository.urosario.edu.co/handle/10336/23672 eng info:eu-repo/semantics/openAccess application/pdf Clinical and Experimental Rheumatology S.A.S. instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Early antigen
Immunoglobulin g antibody
Immunoglobulin m antibody
La antibody
Ro antibody
Antinuclear antibody
Autoantibody
Autoantigen
Protozoon antibody
Ribonucleoprotein
Ss-a antibodies
Ss-b antigen
Virus antibody
Anca associated vasculitis
Antibody titer
Antiphospholipid syndrome
Article
Autoimmune disease
Autoimmune thyroiditis
Celiac disease
Cohort analysis
Controlled study
Cross-sectional study
Cryoglobulinemia
Cytomegalovirus
Epstein barr virus
Geography
Giant cell arteritis
Hepatitis c
Human
Immunoassay
Inflammatory bowel disease
Major clinical study
Polymyositis
Prevalence
Primary biliary cirrhosis
Priority journal
Protein protein interaction
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Toxoplasma
Wegener granulomatosis
Autoimmune disease
Biliary cirrhosis
Blood
Immunology
Antiphospholipid syndrome
Autoantibodies
Autoantigens
Autoimmune diseases
Cohort studies
Cross-sectional studies
Cytomegalovirus
Humans
Ribonucleoproteins
Sjogren's syndrome
Toxoplasma
Anti-la/ssb antibody
Anti-ro/ssa antibody
Antiphospholipid syndrome
Autoimmunity
Sjögren's syndrome
Systemic lupus erythematosus
systemic
antinuclear
viral
biliary
human
protozoan
Antibodies
Antibodies
Antibodies
Herpesvirus 4
Liver cirrhosis
Lupus erythematosus
spellingShingle Early antigen
Immunoglobulin g antibody
Immunoglobulin m antibody
La antibody
Ro antibody
Antinuclear antibody
Autoantibody
Autoantigen
Protozoon antibody
Ribonucleoprotein
Ss-a antibodies
Ss-b antigen
Virus antibody
Anca associated vasculitis
Antibody titer
Antiphospholipid syndrome
Article
Autoimmune disease
Autoimmune thyroiditis
Celiac disease
Cohort analysis
Controlled study
Cross-sectional study
Cryoglobulinemia
Cytomegalovirus
Epstein barr virus
Geography
Giant cell arteritis
Hepatitis c
Human
Immunoassay
Inflammatory bowel disease
Major clinical study
Polymyositis
Prevalence
Primary biliary cirrhosis
Priority journal
Protein protein interaction
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Toxoplasma
Wegener granulomatosis
Autoimmune disease
Biliary cirrhosis
Blood
Immunology
Antiphospholipid syndrome
Autoantibodies
Autoantigens
Autoimmune diseases
Cohort studies
Cross-sectional studies
Cytomegalovirus
Humans
Ribonucleoproteins
Sjogren's syndrome
Toxoplasma
Anti-la/ssb antibody
Anti-ro/ssa antibody
Antiphospholipid syndrome
Autoimmunity
Sjögren's syndrome
Systemic lupus erythematosus
systemic
antinuclear
viral
biliary
human
protozoan
Antibodies
Antibodies
Antibodies
Herpesvirus 4
Liver cirrhosis
Lupus erythematosus
Agmon-Levin N.
Dagan A.
Peri Y.
Anaya, Juan-Manuel
Selmi C.
Tincani A.
Bizzaro N.
Stojanovich L.
Damoiseaux J.
Tervaert J.W.C.
Mosca M.
Cervera R.
Shoenfeld Y.
The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
description Objective The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies Methods We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. All samples were also tested for a variety of anti-infectious agents' antibodies using the BioPlex 2200-immunoassay (Bio-Rad, USA). Results Anti-Ro/SSA was more prevalent, with significantly higher titre in 5 autoimmune diseases namely Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) both primary and APS linked to SLE, systemic sclerosis (SSc) and primary biliary cirrhosis (PBC). Anti-La/SSB was more prevalent with higher titers in SS, SLE, APS linked to SLE and PBC. Prevalence, but not titers, of both antibodies were higher also in polymyositis (PM). Additionally, we found a correlation between anti-Ro/SSA antibodies and antibodies of the IgM and IgG subtypes directed at cytomegalovirus as well as IgG-antibodies directed at Epstein-Barr virus (EBV) and toxoplasma (p less than 0.001). Anti-La/SSB antibodies correlated with the presence of IgG antibodies against EBV early antigen (p less than 0.001). Conclusion In a large cohort of patients with autoimmune diseases we found an association between anti-Ro/SSA and anti-La/SSB antibodies and 6 autoimmune diseases, amongst which primary APS and PM. Additionally, we observed linkages between these autoantibodies and anti-infectious antibodies directed at Epstein-Barr virus, toxoplasma and cytomegalovirus. Our findings support the concept of interplay between infectious agents and autoimmunity, such as the plausibility of an infectious agent that trigger the immune system to produce specific antibodies which will later result in a unique group of AID. © Clinical and Experimental Rheumatology 2017.
format Artículo (Article)
author Agmon-Levin N.
Dagan A.
Peri Y.
Anaya, Juan-Manuel
Selmi C.
Tincani A.
Bizzaro N.
Stojanovich L.
Damoiseaux J.
Tervaert J.W.C.
Mosca M.
Cervera R.
Shoenfeld Y.
author_facet Agmon-Levin N.
Dagan A.
Peri Y.
Anaya, Juan-Manuel
Selmi C.
Tincani A.
Bizzaro N.
Stojanovich L.
Damoiseaux J.
Tervaert J.W.C.
Mosca M.
Cervera R.
Shoenfeld Y.
author_sort Agmon-Levin N.
title The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
title_short The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
title_full The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
title_fullStr The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
title_full_unstemmed The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic
title_sort interaction between anti-ro/ssa and anti-la/ssb autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic
publisher Clinical and Experimental Rheumatology S.A.S.
publishDate 2017
url https://repository.urosario.edu.co/handle/10336/23672
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score 12,131701