Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling

"Low delivery of many anticancer drugs across the blood-brain barrier (BBB) is a limitation to the success of chemotherapy in glioblastoma. This is because of the high levels of ATP-binding cassette transporters like P-glycoprotein (Pgp/ABCB1), which effluxes drugs back to the bloodstream. Temo...

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Detalles Bibliográficos
Autores Principales: "Riganti, Chiara, Salaroglio, Iris C., Pinzòn-Daza, Martha L., Caldera, Valentina, Campia, Ivana, Kopecka, Joanna, Mellai, Marta, Annovazzi, Laura, Couraud, Pierre-Olivier, Bosia, Amalia, Ghigo, Dario, Schiffer, Davide"
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2014
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23644
https://doi.org/10.1007/s00018-013-1397-y