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The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis

Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlle...

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Detalles Bibliográficos
Autores Principales: Meneses-Echávez, Jose F, Correa-Bautista, Jorge E, González-Jiménez, Emilio, Schmidt Río-Valle, Jacqueline, Elkins, Mark R, Lobelo, Felipe, Ramírez-Vélez, Robinson
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: American Association for Cancer Research Inc. 2016
Materias:
C reactive protein
Interleukin 10
Interleukin 2
Interleukin 6
Interleukin 8
Tumor necrosis factor alpha
Autacoid
Aerobic exercise
Breast cancer
Breast carcinogenesis
Cancer survivor
Chronic inflammation
Evidence based practice
Exercise
Human
Inflammation
Mediator release
Meta analysis
Priority journal
Protein blood level
Randomized controlled trial (topic)
Resistance training
Review
Systematic review
Tai Chi
Tumor microenvironment
Yoga
Blood
Breast tumor
Enzyme linked immunosorbent assay
Female
Kinesiotherapy
Middle aged
Mortality
Physiology
Procedures
Regression analysis
Breast Neoplasms
C-Reactive Protein
Cancer Survivors
Enzyme-Linked Immunosorbent Assay
Exercise Therapy
Humans
Inflammation Mediators
Interleukin-10
Interleukin-6
Middle Aged
Randomized Controlled Trials as Topic
Regression Analysis
human
IL10 protein
IL6 protein
Physical Conditioning
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23634
https://doi.org/10.1158/1055-9965.EPI-15-1061
Descripción
Sumario:Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNF? (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. © 2016 American Association for Cancer Research.

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