The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells

"Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy in vivo, because it is extruded by P-glycopro...

Descripción completa

Detalles Bibliográficos
Autores Principales: Pinzón?Daza, ML, Garzón, R, Couraud, PO, Romero, IA, Weksler, B, Ghigo, D, Bosia, A, Riganti, C
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23615
https://doi.org/10.1111/j.1476-5381.2012.02103.x