Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by b...
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2009
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23506 https://doi.org/10.1016/j.bbrc.2009.04.138 |
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ir-10336-235062022-05-02T12:37:21Z Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins Cifuentes, Gladys Vanegas, Magnolia Martinez, Nora Lorena Pirajan, Camilo Patarroyo, Manuel Elkin HLA DR antigen Liver stage antigen 1 Major histocompatibility antigen class 2 Malaria vaccine Parasite antigen Plasmodium falciparum malarial protein Protozoal protein Sporozoite and liver stage antigen T lymphocyte receptor Unclassified drug Animal cell Animal experiment Animal model Animal tissue Antigen structure Article Cell invasion Controlled study Host parasite interaction Immune response Immunogenicity Liver cell Malaria Monkey Nonhuman Nucleotide sequence Plasmodium falciparum Priority journal Sporozoite Amino Acid Sequence Animals HLA-DR Antigens Immunization Liver Malaria Vaccines Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Plasmodium falciparum HLA-dr?1* molecules LSA-1 Malaria MHCII-peptide-TCR complex SALSA Subunit Secondary Protozoan Antigens Protein Structure Vaccines A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasite's access to hepatic cells, and/or proteins involved in the development of this stage, amongst which are included the Liver Stage Antigen-1 (LSA-1) and the Sporozoite and Liver Stage Antigen (SALSA). Our studies have focused on the search for an association between the structure of high activity binding peptides (HABPs), including both conserved native and their modified analogues, and their ability to bind to the MHC Class II HLA-DR molecules during formation of the MHCII-peptide-TCR complex leading to inducing the appropriate immune response. These studies are part of a logical and rational strategy for developing multi-stage, multi-component, minimal subunit-based vaccines, mainly against the P. falciparum malaria. © 2009 Elsevier Inc. All rights reserved. 2009 2020-05-26T00:02:36Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0006291X 10902104 https://repository.urosario.edu.co/handle/10336/23506 https://doi.org/10.1016/j.bbrc.2009.04.138 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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DSpace |
| language |
Inglés (English) |
| topic |
HLA DR antigen Liver stage antigen 1 Major histocompatibility antigen class 2 Malaria vaccine Parasite antigen Plasmodium falciparum malarial protein Protozoal protein Sporozoite and liver stage antigen T lymphocyte receptor Unclassified drug Animal cell Animal experiment Animal model Animal tissue Antigen structure Article Cell invasion Controlled study Host parasite interaction Immune response Immunogenicity Liver cell Malaria Monkey Nonhuman Nucleotide sequence Plasmodium falciparum Priority journal Sporozoite Amino Acid Sequence Animals HLA-DR Antigens Immunization Liver Malaria Vaccines Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Plasmodium falciparum HLA-dr?1* molecules LSA-1 Malaria MHCII-peptide-TCR complex SALSA Subunit Secondary Protozoan Antigens Protein Structure Vaccines |
| spellingShingle |
HLA DR antigen Liver stage antigen 1 Major histocompatibility antigen class 2 Malaria vaccine Parasite antigen Plasmodium falciparum malarial protein Protozoal protein Sporozoite and liver stage antigen T lymphocyte receptor Unclassified drug Animal cell Animal experiment Animal model Animal tissue Antigen structure Article Cell invasion Controlled study Host parasite interaction Immune response Immunogenicity Liver cell Malaria Monkey Nonhuman Nucleotide sequence Plasmodium falciparum Priority journal Sporozoite Amino Acid Sequence Animals HLA-DR Antigens Immunization Liver Malaria Vaccines Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Plasmodium falciparum HLA-dr?1* molecules LSA-1 Malaria MHCII-peptide-TCR complex SALSA Subunit Secondary Protozoan Antigens Protein Structure Vaccines Cifuentes, Gladys Vanegas, Magnolia Martinez, Nora Lorena Pirajan, Camilo Patarroyo, Manuel Elkin Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| description |
A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasite's access to hepatic cells, and/or proteins involved in the development of this stage, amongst which are included the Liver Stage Antigen-1 (LSA-1) and the Sporozoite and Liver Stage Antigen (SALSA). Our studies have focused on the search for an association between the structure of high activity binding peptides (HABPs), including both conserved native and their modified analogues, and their ability to bind to the MHC Class II HLA-DR molecules during formation of the MHCII-peptide-TCR complex leading to inducing the appropriate immune response. These studies are part of a logical and rational strategy for developing multi-stage, multi-component, minimal subunit-based vaccines, mainly against the P. falciparum malaria. © 2009 Elsevier Inc. All rights reserved. |
| format |
Artículo (Article) |
| author |
Cifuentes, Gladys Vanegas, Magnolia Martinez, Nora Lorena Pirajan, Camilo Patarroyo, Manuel Elkin |
| author_facet |
Cifuentes, Gladys Vanegas, Magnolia Martinez, Nora Lorena Pirajan, Camilo Patarroyo, Manuel Elkin |
| author_sort |
Cifuentes, Gladys |
| title |
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| title_short |
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| title_full |
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| title_fullStr |
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| title_full_unstemmed |
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins |
| title_sort |
structural characteristics of immunogenic liver-stage antigens derived from p. falciparum malarial proteins |
| publishDate |
2009 |
| url |
https://repository.urosario.edu.co/handle/10336/23506 https://doi.org/10.1016/j.bbrc.2009.04.138 |
| _version_ |
1740172404305428480 |
| score |
12,111491 |