Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins

A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by b...

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Autores Principales: Cifuentes, Gladys, Vanegas, Magnolia, Martinez, Nora Lorena, Pirajan, Camilo, Patarroyo, Manuel Elkin
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2009
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/23506
https://doi.org/10.1016/j.bbrc.2009.04.138
id ir-10336-23506
recordtype dspace
spelling ir-10336-235062022-05-02T12:37:21Z Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins Cifuentes, Gladys Vanegas, Magnolia Martinez, Nora Lorena Pirajan, Camilo Patarroyo, Manuel Elkin HLA DR antigen Liver stage antigen 1 Major histocompatibility antigen class 2 Malaria vaccine Parasite antigen Plasmodium falciparum malarial protein Protozoal protein Sporozoite and liver stage antigen T lymphocyte receptor Unclassified drug Animal cell Animal experiment Animal model Animal tissue Antigen structure Article Cell invasion Controlled study Host parasite interaction Immune response Immunogenicity Liver cell Malaria Monkey Nonhuman Nucleotide sequence Plasmodium falciparum Priority journal Sporozoite Amino Acid Sequence Animals HLA-DR Antigens Immunization Liver Malaria Vaccines Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Plasmodium falciparum HLA-dr?1* molecules LSA-1 Malaria MHCII-peptide-TCR complex SALSA Subunit Secondary Protozoan Antigens Protein Structure Vaccines A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasite's access to hepatic cells, and/or proteins involved in the development of this stage, amongst which are included the Liver Stage Antigen-1 (LSA-1) and the Sporozoite and Liver Stage Antigen (SALSA). Our studies have focused on the search for an association between the structure of high activity binding peptides (HABPs), including both conserved native and their modified analogues, and their ability to bind to the MHC Class II HLA-DR molecules during formation of the MHCII-peptide-TCR complex leading to inducing the appropriate immune response. These studies are part of a logical and rational strategy for developing multi-stage, multi-component, minimal subunit-based vaccines, mainly against the P. falciparum malaria. © 2009 Elsevier Inc. All rights reserved. 2009 2020-05-26T00:02:36Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0006291X 10902104 https://repository.urosario.edu.co/handle/10336/23506 https://doi.org/10.1016/j.bbrc.2009.04.138 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic HLA DR antigen
Liver stage antigen 1
Major histocompatibility antigen class 2
Malaria vaccine
Parasite antigen
Plasmodium falciparum malarial protein
Protozoal protein
Sporozoite and liver stage antigen
T lymphocyte receptor
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Antigen structure
Article
Cell invasion
Controlled study
Host parasite interaction
Immune response
Immunogenicity
Liver cell
Malaria
Monkey
Nonhuman
Nucleotide sequence
Plasmodium falciparum
Priority journal
Sporozoite
Amino Acid Sequence
Animals
HLA-DR Antigens
Immunization
Liver
Malaria Vaccines
Molecular Sequence Data
Plasmodium falciparum
Protozoan Proteins
Plasmodium falciparum
HLA-dr?1* molecules
LSA-1
Malaria
MHCII-peptide-TCR complex
SALSA
Subunit
Secondary
Protozoan
Antigens
Protein Structure
Vaccines
spellingShingle HLA DR antigen
Liver stage antigen 1
Major histocompatibility antigen class 2
Malaria vaccine
Parasite antigen
Plasmodium falciparum malarial protein
Protozoal protein
Sporozoite and liver stage antigen
T lymphocyte receptor
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Antigen structure
Article
Cell invasion
Controlled study
Host parasite interaction
Immune response
Immunogenicity
Liver cell
Malaria
Monkey
Nonhuman
Nucleotide sequence
Plasmodium falciparum
Priority journal
Sporozoite
Amino Acid Sequence
Animals
HLA-DR Antigens
Immunization
Liver
Malaria Vaccines
Molecular Sequence Data
Plasmodium falciparum
Protozoan Proteins
Plasmodium falciparum
HLA-dr?1* molecules
LSA-1
Malaria
MHCII-peptide-TCR complex
SALSA
Subunit
Secondary
Protozoan
Antigens
Protein Structure
Vaccines
Cifuentes, Gladys
Vanegas, Magnolia
Martinez, Nora Lorena
Pirajan, Camilo
Patarroyo, Manuel Elkin
Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
description A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasite's access to hepatic cells, and/or proteins involved in the development of this stage, amongst which are included the Liver Stage Antigen-1 (LSA-1) and the Sporozoite and Liver Stage Antigen (SALSA). Our studies have focused on the search for an association between the structure of high activity binding peptides (HABPs), including both conserved native and their modified analogues, and their ability to bind to the MHC Class II HLA-DR molecules during formation of the MHCII-peptide-TCR complex leading to inducing the appropriate immune response. These studies are part of a logical and rational strategy for developing multi-stage, multi-component, minimal subunit-based vaccines, mainly against the P. falciparum malaria. © 2009 Elsevier Inc. All rights reserved.
format Artículo (Article)
author Cifuentes, Gladys
Vanegas, Magnolia
Martinez, Nora Lorena
Pirajan, Camilo
Patarroyo, Manuel Elkin
author_facet Cifuentes, Gladys
Vanegas, Magnolia
Martinez, Nora Lorena
Pirajan, Camilo
Patarroyo, Manuel Elkin
author_sort Cifuentes, Gladys
title Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
title_short Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
title_full Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
title_fullStr Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
title_full_unstemmed Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
title_sort structural characteristics of immunogenic liver-stage antigens derived from p. falciparum malarial proteins
publishDate 2009
url https://repository.urosario.edu.co/handle/10336/23506
https://doi.org/10.1016/j.bbrc.2009.04.138
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score 12,111491