Characterisation of the Plasmodium vivax Pv38 antigen
This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23500 https://doi.org/10.1016/j.bbrc.2008.08.163 |
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ir-10336-235002022-05-02T12:37:21Z Characterisation of the Plasmodium vivax Pv38 antigen Mongui, Alvaro Angel, Diana I. Guzman, Catalina Vanegas, Magnolia Patarroyo, Manuel A. Antigen pv38 Parasite antigen Recombinant protein Unclassified drug Amino acid sequence Antigen detection Aotus Article Nonhuman Nucleotide sequence Open reading frame Parasite virulence Plasmodium vivax Priority journal Protein expression Protein isolation Serum Amino acid sequence Animals Molecular sequence data Plasmodium vivax Recombinant proteins Plasmodium falciparum Plasmodium vivax Drms Malaria Plasmodium vivax Pv38 Vaccine candidate protozoan genetic protozoan Antigens Genes Transcription This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved. 2008 2020-05-26T00:02:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0006291X 10902104 https://repository.urosario.edu.co/handle/10336/23500 https://doi.org/10.1016/j.bbrc.2008.08.163 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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DSpace |
language |
Inglés (English) |
topic |
Antigen pv38 Parasite antigen Recombinant protein Unclassified drug Amino acid sequence Antigen detection Aotus Article Nonhuman Nucleotide sequence Open reading frame Parasite virulence Plasmodium vivax Priority journal Protein expression Protein isolation Serum Amino acid sequence Animals Molecular sequence data Plasmodium vivax Recombinant proteins Plasmodium falciparum Plasmodium vivax Drms Malaria Plasmodium vivax Pv38 Vaccine candidate protozoan genetic protozoan Antigens Genes Transcription |
spellingShingle |
Antigen pv38 Parasite antigen Recombinant protein Unclassified drug Amino acid sequence Antigen detection Aotus Article Nonhuman Nucleotide sequence Open reading frame Parasite virulence Plasmodium vivax Priority journal Protein expression Protein isolation Serum Amino acid sequence Animals Molecular sequence data Plasmodium vivax Recombinant proteins Plasmodium falciparum Plasmodium vivax Drms Malaria Plasmodium vivax Pv38 Vaccine candidate protozoan genetic protozoan Antigens Genes Transcription Mongui, Alvaro Angel, Diana I. Guzman, Catalina Vanegas, Magnolia Patarroyo, Manuel A. Characterisation of the Plasmodium vivax Pv38 antigen |
description |
This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved. |
format |
Artículo (Article) |
author |
Mongui, Alvaro Angel, Diana I. Guzman, Catalina Vanegas, Magnolia Patarroyo, Manuel A. |
author_facet |
Mongui, Alvaro Angel, Diana I. Guzman, Catalina Vanegas, Magnolia Patarroyo, Manuel A. |
author_sort |
Mongui, Alvaro |
title |
Characterisation of the Plasmodium vivax Pv38 antigen |
title_short |
Characterisation of the Plasmodium vivax Pv38 antigen |
title_full |
Characterisation of the Plasmodium vivax Pv38 antigen |
title_fullStr |
Characterisation of the Plasmodium vivax Pv38 antigen |
title_full_unstemmed |
Characterisation of the Plasmodium vivax Pv38 antigen |
title_sort |
characterisation of the plasmodium vivax pv38 antigen |
publishDate |
2008 |
url |
https://repository.urosario.edu.co/handle/10336/23500 https://doi.org/10.1016/j.bbrc.2008.08.163 |
_version_ |
1740172299953242112 |
score |
12,131701 |