Characterisation of the Plasmodium vivax Pv38 antigen

This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes...

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Autores Principales: Mongui, Alvaro, Angel, Diana I., Guzman, Catalina, Vanegas, Magnolia, Patarroyo, Manuel A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2008
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23500
https://doi.org/10.1016/j.bbrc.2008.08.163
id ir-10336-23500
recordtype dspace
spelling ir-10336-235002022-05-02T12:37:21Z Characterisation of the Plasmodium vivax Pv38 antigen Mongui, Alvaro Angel, Diana I. Guzman, Catalina Vanegas, Magnolia Patarroyo, Manuel A. Antigen pv38 Parasite antigen Recombinant protein Unclassified drug Amino acid sequence Antigen detection Aotus Article Nonhuman Nucleotide sequence Open reading frame Parasite virulence Plasmodium vivax Priority journal Protein expression Protein isolation Serum Amino acid sequence Animals Molecular sequence data Plasmodium vivax Recombinant proteins Plasmodium falciparum Plasmodium vivax Drms Malaria Plasmodium vivax Pv38 Vaccine candidate protozoan genetic protozoan Antigens Genes Transcription This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved. 2008 2020-05-26T00:02:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0006291X 10902104 https://repository.urosario.edu.co/handle/10336/23500 https://doi.org/10.1016/j.bbrc.2008.08.163 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Antigen pv38
Parasite antigen
Recombinant protein
Unclassified drug
Amino acid sequence
Antigen detection
Aotus
Article
Nonhuman
Nucleotide sequence
Open reading frame
Parasite virulence
Plasmodium vivax
Priority journal
Protein expression
Protein isolation
Serum
Amino acid sequence
Animals
Molecular sequence data
Plasmodium vivax
Recombinant proteins
Plasmodium falciparum
Plasmodium vivax
Drms
Malaria
Plasmodium vivax
Pv38
Vaccine candidate
protozoan
genetic
protozoan
Antigens
Genes
Transcription
spellingShingle Antigen pv38
Parasite antigen
Recombinant protein
Unclassified drug
Amino acid sequence
Antigen detection
Aotus
Article
Nonhuman
Nucleotide sequence
Open reading frame
Parasite virulence
Plasmodium vivax
Priority journal
Protein expression
Protein isolation
Serum
Amino acid sequence
Animals
Molecular sequence data
Plasmodium vivax
Recombinant proteins
Plasmodium falciparum
Plasmodium vivax
Drms
Malaria
Plasmodium vivax
Pv38
Vaccine candidate
protozoan
genetic
protozoan
Antigens
Genes
Transcription
Mongui, Alvaro
Angel, Diana I.
Guzman, Catalina
Vanegas, Magnolia
Patarroyo, Manuel A.
Characterisation of the Plasmodium vivax Pv38 antigen
description This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved.
format Artículo (Article)
author Mongui, Alvaro
Angel, Diana I.
Guzman, Catalina
Vanegas, Magnolia
Patarroyo, Manuel A.
author_facet Mongui, Alvaro
Angel, Diana I.
Guzman, Catalina
Vanegas, Magnolia
Patarroyo, Manuel A.
author_sort Mongui, Alvaro
title Characterisation of the Plasmodium vivax Pv38 antigen
title_short Characterisation of the Plasmodium vivax Pv38 antigen
title_full Characterisation of the Plasmodium vivax Pv38 antigen
title_fullStr Characterisation of the Plasmodium vivax Pv38 antigen
title_full_unstemmed Characterisation of the Plasmodium vivax Pv38 antigen
title_sort characterisation of the plasmodium vivax pv38 antigen
publishDate 2008
url https://repository.urosario.edu.co/handle/10336/23500
https://doi.org/10.1016/j.bbrc.2008.08.163
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score 12,131701