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Identification of conserved erythrocyte binding regions in members of the Plasmodium falciparum Cys6 lipid raft-associated protein family

Detergent-resistant lipid raft membrane-associated Pf12, Pf38 and Pf41 proteins belong to the Cys6 family, whose members are implicated in Plasmodium falciparum invasion to erythrocytes. We have analyzed the interaction between 20-mer-long synthetic peptides spanning the entire Pf12, Pf38 and Pf41 s...

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Detalles Bibliográficos
Autores Principales:	García, Jeison, Curtidor, Hernando, Pinzón, Carlos G., Vanegas, Magnolia, Moreno, Armando, Patarroyo, Manuel E.
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	2009
Materias:	Alanylglycyllysylvalylasparaginylasparaginyllysylvalyl cysteinyllysylisoleucylglutaminylglycyllysylprolylglycylglutamyll eucylvalylglycine Alanylleucylasparaginylarginylphenylalanyllysyllysyl methionyllysylaspartylleucylseryllysylphenylalanylphenylalanyl asparaginylaspartylglutaminylalanylaspartic acid Asparaginylthreonylthreonyllysylleucylasparaginylleucyl prolyllysylserylleucylasparaginylisoleucylprolylasparaginylaspartyl isoleucylleucylasparaginyltyrosinel Cysteine derivative Leucylhistidyllysylasparaginyllysylvalylthreonylaspartyll eucyllysylthreonylleucylisoleucylprolylglycyltyrosylalanylseryltyrosylthreonine Malaria vaccine Membrane protein Methionylaspartylhistidyltyrosylasparaginylasparaginyl threonylphenylalanyltyrosylserylarginylleucylprolylserylleucyl isoleucylserylaspartylasparaginyltryptophan Peptide derivative Pf12 protein Pf38 protein Pf41 protein Tyrosylserylisoleucyllysylprolylaspartylglycylcysteinylphenyl alanylserylasparaginylvalyltyrosylvalyllysylarginyltyrosylprolyl asparaginylglutamine Unclassified drug Valylisoleucylglycylserylserylmethionylphenylalanylmethionyl arginylarginylserylleucylthreonylprolylasparaginyllysylisoleucyl asparaginylglutamylvaline Valylleucylarginylisoleucylhistidylisoleucylserylasparaginyl glycylvalylleucylarginyllysylisoleucylprolylglycylcysteinyl aspartylphenylalanylasparagine Alpha helix Article Beta turn Binding affinity Binding site Erythrocyte Host parasite interaction Human Human cell Lipid raft Malaria Merozoite Plasmodium falciparum Priority journal Protein analysis Protein function Animals Erythrocytes Humans Protein binding Protein interaction mapping Protozoan proteins Antimalarial vaccine Cys6 family High-activity binding peptides Pf12 Pf38 Pf41 protozoan secondary tertiary cell surface Antigens Protein structure Receptors
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/23451 https://doi.org/10.1016/j.vaccine.2009.04.039

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