A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO pr...
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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2007
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23399 https://doi.org/10.1016/j.tube.2007.03.002 |
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ir-10336-233992022-05-02T12:37:13Z A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis Gómez, Luis Miguel Anaya, Juan-Manuel Vilchez, José Ramón Cadena, Jose Hinojosa, Rosa Vélez, Luciano Lopez-Nevot, Miguel Angel Martín, Javier Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis pulmonary Tuberculosis iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved. 2007 2020-05-26T00:01:43Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14729792 https://repository.urosario.edu.co/handle/10336/23399 https://doi.org/10.1016/j.tube.2007.03.002 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis pulmonary Tuberculosis |
| spellingShingle |
Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis pulmonary Tuberculosis Gómez, Luis Miguel Anaya, Juan-Manuel Vilchez, José Ramón Cadena, Jose Hinojosa, Rosa Vélez, Luciano Lopez-Nevot, Miguel Angel Martín, Javier A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| description |
iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved. |
| format |
Artículo (Article) |
| author |
Gómez, Luis Miguel Anaya, Juan-Manuel Vilchez, José Ramón Cadena, Jose Hinojosa, Rosa Vélez, Luciano Lopez-Nevot, Miguel Angel Martín, Javier |
| author_facet |
Gómez, Luis Miguel Anaya, Juan-Manuel Vilchez, José Ramón Cadena, Jose Hinojosa, Rosa Vélez, Luciano Lopez-Nevot, Miguel Angel Martín, Javier |
| author_sort |
Gómez, Luis Miguel |
| title |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| title_short |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| title_full |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| title_fullStr |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| title_full_unstemmed |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| title_sort |
polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
| publishDate |
2007 |
| url |
https://repository.urosario.edu.co/handle/10336/23399 https://doi.org/10.1016/j.tube.2007.03.002 |
| _version_ |
1740172756607041536 |
| score |
12,131701 |