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Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats

Antidepressants are among the most-prescribed class of drugs in the world and though weight gain is a common outcome of antidepressant treatment, that effect is not well understood. We employed an animal model comprised of 2 weeks of chronic restraint stress with antidepressant treatment, followed b...

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Detalles Bibliográficos
Autores Principales: Lee, S. H., Mastronardi, C. A., Li, R. W., Paz-Filho, G., Dutcher, E. G., Lewis, M. D., Vincent, A. D., Smith, P. N., Bornstein, S. R., Licinio, J., Wong, M. L.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Nature Publishing Group 2019
Materias:
Fluoxetine
Imipramine
Insulin growth factor 1
Leptin
Somatomedin
Triacylglycerol
Unclassified drug
Antidepressant agent
Allometry
Animal experiment
Animal model
Animal tissue
Anxiety
Article
Body weight gain
Bone growth
Bone length
Bone mineral
Bone structure
Catch up growth
Chronic stress
Controlled study
Cortical bone
Diet induced obesity
Distal femur
Fat mass
Femur metaphysis
Food intake
Immobilization stress
Lean body weight
Lipolysis
Male
Mrna expression level
Nonhuman
Ossification
Rat
Trabecular bone
Treatment duration
Triacylglycerol blood level
Animal
Animal behavior
Bone density
Disease model
Drug effect
Drug therapy
Mental stress
Metabolism
Obesity
Sprague dawley rat
Animals
Antidepressive agents
Rats
Weight gain
sprague-dawley
animal
psychological
Behavior
Disease models
Stress
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23390
https://doi.org/10.1038/s41398-018-0351-z

Internet

https://repository.urosario.edu.co/handle/10336/23390
https://doi.org/10.1038/s41398-018-0351-z

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