Factors influencing polyautoimmunity in systemic lupus erythematosus

Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lu...

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Autores Principales: Rojas-Villarraga, Adriana, Duarte-Rey, Carolina, Toro, Carlos-Enrique, Espinosa, Gerard, Rodríguez-Velosa, Yolima, Mantilla, Rubén D., Iglesias-Gamarra, Antonio, Cervera, Ricard, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2010
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/23389
https://doi.org/10.1016/j.autrev.2009.10.001
id ir-10336-23389
recordtype dspace
spelling ir-10336-233892022-05-02T12:37:13Z Factors influencing polyautoimmunity in systemic lupus erythematosus Rojas-Villarraga, Adriana Duarte-Rey, Carolina Toro, Carlos-Enrique Espinosa, Gerard Rodríguez-Velosa, Yolima Mantilla, Rubén D. Iglesias-Gamarra, Antonio Cervera, Ricard Anaya, Juan-Manuel Ribonucleoprotein antibody Ro antibody Antiphospholipid syndrome Autoimmune thyroiditis Autoimmunity Clinical feature Cluster analysis Cross-sectional study Disease association Disease predisposition Human Pathophysiology Phenotype Review Risk factor Sex difference Sjoegren syndrome Systemic lupus erythematosus Autoantibodies Autoimmunity Cross-sectional studies Ethnic groups Female Humans Male Multivariate analysis Prevalence Risk factors Sjogren's syndrome Familial autoimmunity Multiple autoimmune syndrome Polyautoimmunity Systemic lupus erythematosus autoimmune systemic Lupus erythematosus Thyroiditis Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved. 2010 2020-05-26T00:01:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23389 https://doi.org/10.1016/j.autrev.2009.10.001 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
autoimmune
systemic
Lupus erythematosus
Thyroiditis
spellingShingle Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
autoimmune
systemic
Lupus erythematosus
Thyroiditis
Rojas-Villarraga, Adriana
Duarte-Rey, Carolina
Toro, Carlos-Enrique
Espinosa, Gerard
Rodríguez-Velosa, Yolima
Mantilla, Rubén D.
Iglesias-Gamarra, Antonio
Cervera, Ricard
Anaya, Juan-Manuel
Factors influencing polyautoimmunity in systemic lupus erythematosus
description Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.
format Artículo (Article)
author Rojas-Villarraga, Adriana
Duarte-Rey, Carolina
Toro, Carlos-Enrique
Espinosa, Gerard
Rodríguez-Velosa, Yolima
Mantilla, Rubén D.
Iglesias-Gamarra, Antonio
Cervera, Ricard
Anaya, Juan-Manuel
author_facet Rojas-Villarraga, Adriana
Duarte-Rey, Carolina
Toro, Carlos-Enrique
Espinosa, Gerard
Rodríguez-Velosa, Yolima
Mantilla, Rubén D.
Iglesias-Gamarra, Antonio
Cervera, Ricard
Anaya, Juan-Manuel
author_sort Rojas-Villarraga, Adriana
title Factors influencing polyautoimmunity in systemic lupus erythematosus
title_short Factors influencing polyautoimmunity in systemic lupus erythematosus
title_full Factors influencing polyautoimmunity in systemic lupus erythematosus
title_fullStr Factors influencing polyautoimmunity in systemic lupus erythematosus
title_full_unstemmed Factors influencing polyautoimmunity in systemic lupus erythematosus
title_sort factors influencing polyautoimmunity in systemic lupus erythematosus
publishDate 2010
url https://repository.urosario.edu.co/handle/10336/23389
https://doi.org/10.1016/j.autrev.2009.10.001
_version_ 1740172740668686336
score 12,131701