Factors influencing polyautoimmunity in systemic lupus erythematosus
Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lu...
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ir-10336-233892022-05-02T12:37:13Z Factors influencing polyautoimmunity in systemic lupus erythematosus Rojas-Villarraga, Adriana Duarte-Rey, Carolina Toro, Carlos-Enrique Espinosa, Gerard Rodríguez-Velosa, Yolima Mantilla, Rubén D. Iglesias-Gamarra, Antonio Cervera, Ricard Anaya, Juan-Manuel Ribonucleoprotein antibody Ro antibody Antiphospholipid syndrome Autoimmune thyroiditis Autoimmunity Clinical feature Cluster analysis Cross-sectional study Disease association Disease predisposition Human Pathophysiology Phenotype Review Risk factor Sex difference Sjoegren syndrome Systemic lupus erythematosus Autoantibodies Autoimmunity Cross-sectional studies Ethnic groups Female Humans Male Multivariate analysis Prevalence Risk factors Sjogren's syndrome Familial autoimmunity Multiple autoimmune syndrome Polyautoimmunity Systemic lupus erythematosus autoimmune systemic Lupus erythematosus Thyroiditis Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved. 2010 2020-05-26T00:01:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23389 https://doi.org/10.1016/j.autrev.2009.10.001 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Ribonucleoprotein antibody Ro antibody Antiphospholipid syndrome Autoimmune thyroiditis Autoimmunity Clinical feature Cluster analysis Cross-sectional study Disease association Disease predisposition Human Pathophysiology Phenotype Review Risk factor Sex difference Sjoegren syndrome Systemic lupus erythematosus Autoantibodies Autoimmunity Cross-sectional studies Ethnic groups Female Humans Male Multivariate analysis Prevalence Risk factors Sjogren's syndrome Familial autoimmunity Multiple autoimmune syndrome Polyautoimmunity Systemic lupus erythematosus autoimmune systemic Lupus erythematosus Thyroiditis |
spellingShingle |
Ribonucleoprotein antibody Ro antibody Antiphospholipid syndrome Autoimmune thyroiditis Autoimmunity Clinical feature Cluster analysis Cross-sectional study Disease association Disease predisposition Human Pathophysiology Phenotype Review Risk factor Sex difference Sjoegren syndrome Systemic lupus erythematosus Autoantibodies Autoimmunity Cross-sectional studies Ethnic groups Female Humans Male Multivariate analysis Prevalence Risk factors Sjogren's syndrome Familial autoimmunity Multiple autoimmune syndrome Polyautoimmunity Systemic lupus erythematosus autoimmune systemic Lupus erythematosus Thyroiditis Rojas-Villarraga, Adriana Duarte-Rey, Carolina Toro, Carlos-Enrique Espinosa, Gerard Rodríguez-Velosa, Yolima Mantilla, Rubén D. Iglesias-Gamarra, Antonio Cervera, Ricard Anaya, Juan-Manuel Factors influencing polyautoimmunity in systemic lupus erythematosus |
description |
Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved. |
format |
Artículo (Article) |
author |
Rojas-Villarraga, Adriana Duarte-Rey, Carolina Toro, Carlos-Enrique Espinosa, Gerard Rodríguez-Velosa, Yolima Mantilla, Rubén D. Iglesias-Gamarra, Antonio Cervera, Ricard Anaya, Juan-Manuel |
author_facet |
Rojas-Villarraga, Adriana Duarte-Rey, Carolina Toro, Carlos-Enrique Espinosa, Gerard Rodríguez-Velosa, Yolima Mantilla, Rubén D. Iglesias-Gamarra, Antonio Cervera, Ricard Anaya, Juan-Manuel |
author_sort |
Rojas-Villarraga, Adriana |
title |
Factors influencing polyautoimmunity in systemic lupus erythematosus |
title_short |
Factors influencing polyautoimmunity in systemic lupus erythematosus |
title_full |
Factors influencing polyautoimmunity in systemic lupus erythematosus |
title_fullStr |
Factors influencing polyautoimmunity in systemic lupus erythematosus |
title_full_unstemmed |
Factors influencing polyautoimmunity in systemic lupus erythematosus |
title_sort |
factors influencing polyautoimmunity in systemic lupus erythematosus |
publishDate |
2010 |
url |
https://repository.urosario.edu.co/handle/10336/23389 https://doi.org/10.1016/j.autrev.2009.10.001 |
_version_ |
1740172740668686336 |
score |
12,131701 |