Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review

Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further...

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Autores Principales: Amaya-Amaya, Jenny, Calixto, Omar-Javier, Saade-Lemus, Sandra, Calvo-Paramo, Enrique, Mantilla, Ruben-Dario, Rojas-Villarraga, Adriana, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: W.B. Saunders 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23295
https://doi.org/10.1016/j.semarthrit.2014.09.006
id ir-10336-23295
recordtype dspace
spelling ir-10336-232952022-05-02T12:37:13Z Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review Amaya-Amaya, Jenny Calixto, Omar-Javier Saade-Lemus, Sandra Calvo-Paramo, Enrique Mantilla, Ruben-Dario Rojas-Villarraga, Adriana Anaya, Juan-Manuel Antinuclear antibody C reactive protein Rheumatoid factor Autoantibody Adult Age distribution Article Asia Clinical evaluation Colombia Computer assisted tomography Cross-sectional study Disease duration Echography Europe Female Human Major clinical study Male Mexico Non erosive rheumatoid arthritis Onset age Population research Prevalence Priority journal Rheumatoid arthritis South and central america Systematic review (topic) Visual analog scale X ray Bone Immunology Middle aged Radiography Rheumatoid arthritis Adult Autoantibodies Bone and bones Female Humans Male Middle aged Computed tomography Erosions Rheumatoid arthritis Ultrasonography X-ray rheumatoid Arthritis Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc. 2015 2020-05-26T00:00:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 490172 https://repository.urosario.edu.co/handle/10336/23295 https://doi.org/10.1016/j.semarthrit.2014.09.006 eng info:eu-repo/semantics/openAccess application/pdf W.B. Saunders instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
spellingShingle Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
Amaya-Amaya, Jenny
Calixto, Omar-Javier
Saade-Lemus, Sandra
Calvo-Paramo, Enrique
Mantilla, Ruben-Dario
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
description Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc.
format Artículo (Article)
author Amaya-Amaya, Jenny
Calixto, Omar-Javier
Saade-Lemus, Sandra
Calvo-Paramo, Enrique
Mantilla, Ruben-Dario
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_facet Amaya-Amaya, Jenny
Calixto, Omar-Javier
Saade-Lemus, Sandra
Calvo-Paramo, Enrique
Mantilla, Ruben-Dario
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_sort Amaya-Amaya, Jenny
title Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_short Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_full Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_fullStr Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_full_unstemmed Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_sort does non-erosive rheumatoid arthritis exist? a cross-sectional analysis and a systematic literature review
publisher W.B. Saunders
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/23295
https://doi.org/10.1016/j.semarthrit.2014.09.006
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score 12,111491