Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further...
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| Lenguaje: | Inglés (English) |
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W.B. Saunders
2015
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23295 https://doi.org/10.1016/j.semarthrit.2014.09.006 |
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ir-10336-232952022-05-02T12:37:13Z Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review Amaya-Amaya, Jenny Calixto, Omar-Javier Saade-Lemus, Sandra Calvo-Paramo, Enrique Mantilla, Ruben-Dario Rojas-Villarraga, Adriana Anaya, Juan-Manuel Antinuclear antibody C reactive protein Rheumatoid factor Autoantibody Adult Age distribution Article Asia Clinical evaluation Colombia Computer assisted tomography Cross-sectional study Disease duration Echography Europe Female Human Major clinical study Male Mexico Non erosive rheumatoid arthritis Onset age Population research Prevalence Priority journal Rheumatoid arthritis South and central america Systematic review (topic) Visual analog scale X ray Bone Immunology Middle aged Radiography Rheumatoid arthritis Adult Autoantibodies Bone and bones Female Humans Male Middle aged Computed tomography Erosions Rheumatoid arthritis Ultrasonography X-ray rheumatoid Arthritis Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc. 2015 2020-05-26T00:00:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 490172 https://repository.urosario.edu.co/handle/10336/23295 https://doi.org/10.1016/j.semarthrit.2014.09.006 eng info:eu-repo/semantics/openAccess application/pdf W.B. Saunders instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Antinuclear antibody C reactive protein Rheumatoid factor Autoantibody Adult Age distribution Article Asia Clinical evaluation Colombia Computer assisted tomography Cross-sectional study Disease duration Echography Europe Female Human Major clinical study Male Mexico Non erosive rheumatoid arthritis Onset age Population research Prevalence Priority journal Rheumatoid arthritis South and central america Systematic review (topic) Visual analog scale X ray Bone Immunology Middle aged Radiography Rheumatoid arthritis Adult Autoantibodies Bone and bones Female Humans Male Middle aged Computed tomography Erosions Rheumatoid arthritis Ultrasonography X-ray rheumatoid Arthritis |
| spellingShingle |
Antinuclear antibody C reactive protein Rheumatoid factor Autoantibody Adult Age distribution Article Asia Clinical evaluation Colombia Computer assisted tomography Cross-sectional study Disease duration Echography Europe Female Human Major clinical study Male Mexico Non erosive rheumatoid arthritis Onset age Population research Prevalence Priority journal Rheumatoid arthritis South and central america Systematic review (topic) Visual analog scale X ray Bone Immunology Middle aged Radiography Rheumatoid arthritis Adult Autoantibodies Bone and bones Female Humans Male Middle aged Computed tomography Erosions Rheumatoid arthritis Ultrasonography X-ray rheumatoid Arthritis Amaya-Amaya, Jenny Calixto, Omar-Javier Saade-Lemus, Sandra Calvo-Paramo, Enrique Mantilla, Ruben-Dario Rojas-Villarraga, Adriana Anaya, Juan-Manuel Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| description |
Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc. |
| format |
Artículo (Article) |
| author |
Amaya-Amaya, Jenny Calixto, Omar-Javier Saade-Lemus, Sandra Calvo-Paramo, Enrique Mantilla, Ruben-Dario Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
| author_facet |
Amaya-Amaya, Jenny Calixto, Omar-Javier Saade-Lemus, Sandra Calvo-Paramo, Enrique Mantilla, Ruben-Dario Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
| author_sort |
Amaya-Amaya, Jenny |
| title |
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| title_short |
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| title_full |
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| title_fullStr |
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| title_full_unstemmed |
Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review |
| title_sort |
does non-erosive rheumatoid arthritis exist? a cross-sectional analysis and a systematic literature review |
| publisher |
W.B. Saunders |
| publishDate |
2015 |
| url |
https://repository.urosario.edu.co/handle/10336/23295 https://doi.org/10.1016/j.semarthrit.2014.09.006 |
| _version_ |
1740172281895714816 |
| score |
12,111491 |