Zika virus and autoimmunity. One-step forward
Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmuni...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23267 https://doi.org/10.1016/j.autrev.2017.10.008 |
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ir-10336-232672021-10-06T22:20:33Z Zika virus and autoimmunity. One-step forward Monsalve, Diana M. Pacheco Y. Acosta-Ampudia, Yeny Rodríguez Y. Ramirez-Santana, Carolina Anaya, Juan-Manuel Autoantibody Adult Autoimmune disease Autoimmunity Case control study Clinical article Controlled study Data extraction Female Guillain barre syndrome Human Idiopathic thrombocytopenic purpura Immunomodulation Information processing Male Medical literature Molecular mimicry Nervous system electrophysiology Phenotype Review Rheumatic disease Thyroid disease Zika fever Zika virus Complication Immunology Autoimmunity Guillain-barre syndrome Humans Molecular mimicry Zika virus infection Autoantibodies Autoimmunity Guillain-barré syndrome Idiopathic thrombocytopenic purpura Thrombocytopenia Zika virus thrombocytopenic idiopathic Purpura Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted. 2017 2020-05-26T00:00:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23267 https://doi.org/10.1016/j.autrev.2017.10.008 eng info:eu-repo/semantics/openAccess application/pdf Elsevier B.V. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Autoantibody Adult Autoimmune disease Autoimmunity Case control study Clinical article Controlled study Data extraction Female Guillain barre syndrome Human Idiopathic thrombocytopenic purpura Immunomodulation Information processing Male Medical literature Molecular mimicry Nervous system electrophysiology Phenotype Review Rheumatic disease Thyroid disease Zika fever Zika virus Complication Immunology Autoimmunity Guillain-barre syndrome Humans Molecular mimicry Zika virus infection Autoantibodies Autoimmunity Guillain-barré syndrome Idiopathic thrombocytopenic purpura Thrombocytopenia Zika virus thrombocytopenic idiopathic Purpura |
spellingShingle |
Autoantibody Adult Autoimmune disease Autoimmunity Case control study Clinical article Controlled study Data extraction Female Guillain barre syndrome Human Idiopathic thrombocytopenic purpura Immunomodulation Information processing Male Medical literature Molecular mimicry Nervous system electrophysiology Phenotype Review Rheumatic disease Thyroid disease Zika fever Zika virus Complication Immunology Autoimmunity Guillain-barre syndrome Humans Molecular mimicry Zika virus infection Autoantibodies Autoimmunity Guillain-barré syndrome Idiopathic thrombocytopenic purpura Thrombocytopenia Zika virus thrombocytopenic idiopathic Purpura Monsalve, Diana M. Pacheco Y. Acosta-Ampudia, Yeny Rodríguez Y. Ramirez-Santana, Carolina Anaya, Juan-Manuel Zika virus and autoimmunity. One-step forward |
description |
Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted. |
format |
Artículo (Article) |
author |
Monsalve, Diana M. Pacheco Y. Acosta-Ampudia, Yeny Rodríguez Y. Ramirez-Santana, Carolina Anaya, Juan-Manuel |
author_facet |
Monsalve, Diana M. Pacheco Y. Acosta-Ampudia, Yeny Rodríguez Y. Ramirez-Santana, Carolina Anaya, Juan-Manuel |
author_sort |
Monsalve, Diana M. |
title |
Zika virus and autoimmunity. One-step forward |
title_short |
Zika virus and autoimmunity. One-step forward |
title_full |
Zika virus and autoimmunity. One-step forward |
title_fullStr |
Zika virus and autoimmunity. One-step forward |
title_full_unstemmed |
Zika virus and autoimmunity. One-step forward |
title_sort |
zika virus and autoimmunity. one-step forward |
publisher |
Elsevier B.V. |
publishDate |
2017 |
url |
https://repository.urosario.edu.co/handle/10336/23267 https://doi.org/10.1016/j.autrev.2017.10.008 |
_version_ |
1723228630398533632 |
score |
12,131701 |