Zika virus and autoimmunity. One-step forward

Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmuni...

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Autores Principales: Monsalve, Diana M., Pacheco Y., Acosta-Ampudia, Yeny, Rodríguez Y., Ramirez-Santana, Carolina, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier B.V. 2017
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23267
https://doi.org/10.1016/j.autrev.2017.10.008
id ir-10336-23267
recordtype dspace
spelling ir-10336-232672021-10-06T22:20:33Z Zika virus and autoimmunity. One-step forward Monsalve, Diana M. Pacheco Y. Acosta-Ampudia, Yeny Rodríguez Y. Ramirez-Santana, Carolina Anaya, Juan-Manuel Autoantibody Adult Autoimmune disease Autoimmunity Case control study Clinical article Controlled study Data extraction Female Guillain barre syndrome Human Idiopathic thrombocytopenic purpura Immunomodulation Information processing Male Medical literature Molecular mimicry Nervous system electrophysiology Phenotype Review Rheumatic disease Thyroid disease Zika fever Zika virus Complication Immunology Autoimmunity Guillain-barre syndrome Humans Molecular mimicry Zika virus infection Autoantibodies Autoimmunity Guillain-barré syndrome Idiopathic thrombocytopenic purpura Thrombocytopenia Zika virus thrombocytopenic idiopathic Purpura Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted. 2017 2020-05-26T00:00:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23267 https://doi.org/10.1016/j.autrev.2017.10.008 eng info:eu-repo/semantics/openAccess application/pdf Elsevier B.V. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Autoantibody
Adult
Autoimmune disease
Autoimmunity
Case control study
Clinical article
Controlled study
Data extraction
Female
Guillain barre syndrome
Human
Idiopathic thrombocytopenic purpura
Immunomodulation
Information processing
Male
Medical literature
Molecular mimicry
Nervous system electrophysiology
Phenotype
Review
Rheumatic disease
Thyroid disease
Zika fever
Zika virus
Complication
Immunology
Autoimmunity
Guillain-barre syndrome
Humans
Molecular mimicry
Zika virus infection
Autoantibodies
Autoimmunity
Guillain-barré syndrome
Idiopathic thrombocytopenic purpura
Thrombocytopenia
Zika virus
thrombocytopenic
idiopathic
Purpura
spellingShingle Autoantibody
Adult
Autoimmune disease
Autoimmunity
Case control study
Clinical article
Controlled study
Data extraction
Female
Guillain barre syndrome
Human
Idiopathic thrombocytopenic purpura
Immunomodulation
Information processing
Male
Medical literature
Molecular mimicry
Nervous system electrophysiology
Phenotype
Review
Rheumatic disease
Thyroid disease
Zika fever
Zika virus
Complication
Immunology
Autoimmunity
Guillain-barre syndrome
Humans
Molecular mimicry
Zika virus infection
Autoantibodies
Autoimmunity
Guillain-barré syndrome
Idiopathic thrombocytopenic purpura
Thrombocytopenia
Zika virus
thrombocytopenic
idiopathic
Purpura
Monsalve, Diana M.
Pacheco Y.
Acosta-Ampudia, Yeny
Rodríguez Y.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
Zika virus and autoimmunity. One-step forward
description Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted.
format Artículo (Article)
author Monsalve, Diana M.
Pacheco Y.
Acosta-Ampudia, Yeny
Rodríguez Y.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
author_facet Monsalve, Diana M.
Pacheco Y.
Acosta-Ampudia, Yeny
Rodríguez Y.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
author_sort Monsalve, Diana M.
title Zika virus and autoimmunity. One-step forward
title_short Zika virus and autoimmunity. One-step forward
title_full Zika virus and autoimmunity. One-step forward
title_fullStr Zika virus and autoimmunity. One-step forward
title_full_unstemmed Zika virus and autoimmunity. One-step forward
title_sort zika virus and autoimmunity. one-step forward
publisher Elsevier B.V.
publishDate 2017
url https://repository.urosario.edu.co/handle/10336/23267
https://doi.org/10.1016/j.autrev.2017.10.008
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score 12,131701