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Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture

Whole exome sequencing (WES) is a widely used strategy for detection of protein coding and splicing variants associated with inherited diseases. Many studies have shown that the strategy has been broad and proficient due to its ability in detecting a high proportion of disease causing variants, usin...

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Detalles Bibliográficos
Autores Principales: Johar, Angad S., Anaya, Juan-Manuel, Andrews, Dan, Patel, Hardip R., Field, Matthew, Goodnow, Chris, Arcos-Burgos, Mauricio
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier 2015
Materias:
Autoimmune disease
Autoimmunity
Bioinformatics
Exome
Gene mapping
Genetic variability
Human
Next generation sequencing
Nonhuman
Phenotype
Review
Sequence analysis
Whole exome sequencing
Dna sequence
Genomics
High throughput sequencing
High-throughput nucleotide sequencing
Humans
Multiple autoimmune syndrome
Polyautoimmunity
Whole genome sequencing
dna
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23234
https://doi.org/10.1016/j.autrev.2014.10.021

Internet

https://repository.urosario.edu.co/handle/10336/23234
https://doi.org/10.1016/j.autrev.2014.10.021

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