Autoimmune diseases in the intensive care unit. An update

"Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of adm...

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Autores Principales: "Quintero, Olga L., Rojas-Villarraga, Adriana, Mantilla, Ruben D., Anaya, Juan-Manuel"
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2013
Materias:
Age
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23188
https://doi.org/10.1016/j.autrev.2012.06.002
id ir-10336-23188
recordtype dspace
spelling ir-10336-231882020-06-03T22:15:09Z Autoimmune diseases in the intensive care unit. An update "Quintero, Olga L. Rojas-Villarraga, Adriana Mantilla, Ruben D. Anaya, Juan-Manuel" Age Apache Autoimmune disease Clinical feature Cytopenia Hospital admission Human Intensive care Intensive care unit Medline Mortality Multiple organ failure Outcome assessment Review Rheumatoid arthritis Scoring system Systematic review Systemic lupus erythematosus Systemic vasculitis Treatment planning Autoimmune diseases Humans Intensive care units Autoimmune diseases Intensive care unit Intravenous immunoglobulins Mortality Outcome Therapeutic plasma exchange "Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of admission, clinical features, outcomes and variables associated with mortality of patients with ADs admitted to the intensive care unit (ICU). International classification criteria for ADs were used to include patients. Search was done through PubMed, SCOPUS, SciELO, and LILACS databases up to December of 2011.Twenty-nine case series and forty-one case reports were analyzed after quality assessment. Respiratory involvement was the leading cause of admission. Systemic lupus erythematosus (SLE) (33.5% of reported patients), rheumatoid arthritis (25%) and systemic vasculitis (15%) were the most frequent ADs in patients admitted to the ICU in the last decade. Mortality ranged from 17% to 55% in case series including all ADs, but in the ones that only included patients with a specific AD, such as SLE, it reached up to 79%. High APACHE score, multi-organ dysfunction, older age and cytopenia were the most reported variables associated with mortality. In conclusion, ADs should always be considered in patients with life threatening conditions that warrant critical care. Variables influencing mortality should be promptly identified in order to improve the patients' outcomes. © 2012 Elsevier B.V." 2013 2020-05-26T00:00:15Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23188 https://doi.org/10.1016/j.autrev.2012.06.002 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Age
Apache
Autoimmune disease
Clinical feature
Cytopenia
Hospital admission
Human
Intensive care
Intensive care unit
Medline
Mortality
Multiple organ failure
Outcome assessment
Review
Rheumatoid arthritis
Scoring system
Systematic review
Systemic lupus erythematosus
Systemic vasculitis
Treatment planning
Autoimmune diseases
Humans
Intensive care units
Autoimmune diseases
Intensive care unit
Intravenous immunoglobulins
Mortality
Outcome
Therapeutic plasma exchange
spellingShingle Age
Apache
Autoimmune disease
Clinical feature
Cytopenia
Hospital admission
Human
Intensive care
Intensive care unit
Medline
Mortality
Multiple organ failure
Outcome assessment
Review
Rheumatoid arthritis
Scoring system
Systematic review
Systemic lupus erythematosus
Systemic vasculitis
Treatment planning
Autoimmune diseases
Humans
Intensive care units
Autoimmune diseases
Intensive care unit
Intravenous immunoglobulins
Mortality
Outcome
Therapeutic plasma exchange
"Quintero, Olga L.
Rojas-Villarraga, Adriana
Mantilla, Ruben D.
Anaya, Juan-Manuel"
Autoimmune diseases in the intensive care unit. An update
description "Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of admission, clinical features, outcomes and variables associated with mortality of patients with ADs admitted to the intensive care unit (ICU). International classification criteria for ADs were used to include patients. Search was done through PubMed, SCOPUS, SciELO, and LILACS databases up to December of 2011.Twenty-nine case series and forty-one case reports were analyzed after quality assessment. Respiratory involvement was the leading cause of admission. Systemic lupus erythematosus (SLE) (33.5% of reported patients), rheumatoid arthritis (25%) and systemic vasculitis (15%) were the most frequent ADs in patients admitted to the ICU in the last decade. Mortality ranged from 17% to 55% in case series including all ADs, but in the ones that only included patients with a specific AD, such as SLE, it reached up to 79%. High APACHE score, multi-organ dysfunction, older age and cytopenia were the most reported variables associated with mortality. In conclusion, ADs should always be considered in patients with life threatening conditions that warrant critical care. Variables influencing mortality should be promptly identified in order to improve the patients' outcomes. © 2012 Elsevier B.V."
format Artículo (Article)
author "Quintero, Olga L.
Rojas-Villarraga, Adriana
Mantilla, Ruben D.
Anaya, Juan-Manuel"
author_facet "Quintero, Olga L.
Rojas-Villarraga, Adriana
Mantilla, Ruben D.
Anaya, Juan-Manuel"
author_sort "Quintero, Olga L.
title Autoimmune diseases in the intensive care unit. An update
title_short Autoimmune diseases in the intensive care unit. An update
title_full Autoimmune diseases in the intensive care unit. An update
title_fullStr Autoimmune diseases in the intensive care unit. An update
title_full_unstemmed Autoimmune diseases in the intensive care unit. An update
title_sort autoimmune diseases in the intensive care unit. an update
publishDate 2013
url https://repository.urosario.edu.co/handle/10336/23188
https://doi.org/10.1016/j.autrev.2012.06.002
_version_ 1669098332649160704
score 11,387785