IgM predominance in autoimmune disease: Genetics and gender

The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations...

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Autores Principales: Duarte-Rey, Carolina, Bogdanos, Dimitrios P., Leung, Patrick S.C., Anaya, Juan-Manuel, Gershwin, M. Eric
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
xxx
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23177
https://doi.org/10.1016/j.autrev.2011.12.001
id ir-10336-23177
recordtype dspace
spelling ir-10336-231772022-05-02T12:37:13Z IgM predominance in autoimmune disease: Genetics and gender Duarte-Rey, Carolina Bogdanos, Dimitrios P. Leung, Patrick S.C. Anaya, Juan-Manuel Gershwin, M. Eric Activation induced cytidine deaminase Alpha interferon Antinuclear antibody Antivirus agent Cd40 antigen Cd40 ligand Complement component c3b I kappa b kinase gamma Immunoglobulin Immunoglobulin m Rheumatoid factor Rituximab Smooth muscle antibody Thyroid hormone Antiviral therapy Arthritis Autoimmune disease Autoimmune hemolytic anemia Autoimmune hepatitis Autoimmune thrombocytopenia Autoimmune thyroiditis B lymphocyte Cd4+ t lymphocyte Cell selection Chronic diarrhea Coombs positive hemolytic anemia Cryoglobulinemia Discoid lupus erythematosus Enteritis Gender Gene expression Gene mutation Hashimoto disease Hepatitis c Hormone substitution Human Hyper igm syndrome Hypothyroidism Immunoglobulin m deficiency Infection Interstitial pneumonia Liver injury Lymphoproliferative disease Multiple sclerosis Nephritis Nonhuman Plasmapheresis Primary biliary cirrhosis Review Rheumatoid arthritis Stem cell transplantation Systemic lupus erythematosus X chromosome Autoimmune diseases B-lymphocytes Female Humans Hyper-igm immunodeficiency syndrome Immunoglobulin m Male Sex factors Autoimmune disease Autoimmune hemolytic anemia Cryoglobulinemia Immunoglobulin m Multiple sclerosis Primary biliary cirrhosis xxx Karyotype 47 The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V. 2012 2020-05-26T00:00:12Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23177 https://doi.org/10.1016/j.autrev.2011.12.001 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Activation induced cytidine deaminase
Alpha interferon
Antinuclear antibody
Antivirus agent
Cd40 antigen
Cd40 ligand
Complement component c3b
I kappa b kinase gamma
Immunoglobulin
Immunoglobulin m
Rheumatoid factor
Rituximab
Smooth muscle antibody
Thyroid hormone
Antiviral therapy
Arthritis
Autoimmune disease
Autoimmune hemolytic anemia
Autoimmune hepatitis
Autoimmune thrombocytopenia
Autoimmune thyroiditis
B lymphocyte
Cd4+ t lymphocyte
Cell selection
Chronic diarrhea
Coombs positive hemolytic anemia
Cryoglobulinemia
Discoid lupus erythematosus
Enteritis
Gender
Gene expression
Gene mutation
Hashimoto disease
Hepatitis c
Hormone substitution
Human
Hyper igm syndrome
Hypothyroidism
Immunoglobulin m deficiency
Infection
Interstitial pneumonia
Liver injury
Lymphoproliferative disease
Multiple sclerosis
Nephritis
Nonhuman
Plasmapheresis
Primary biliary cirrhosis
Review
Rheumatoid arthritis
Stem cell transplantation
Systemic lupus erythematosus
X chromosome
Autoimmune diseases
B-lymphocytes
Female
Humans
Hyper-igm immunodeficiency syndrome
Immunoglobulin m
Male
Sex factors
Autoimmune disease
Autoimmune hemolytic anemia
Cryoglobulinemia
Immunoglobulin m
Multiple sclerosis
Primary biliary cirrhosis
xxx
Karyotype 47
spellingShingle Activation induced cytidine deaminase
Alpha interferon
Antinuclear antibody
Antivirus agent
Cd40 antigen
Cd40 ligand
Complement component c3b
I kappa b kinase gamma
Immunoglobulin
Immunoglobulin m
Rheumatoid factor
Rituximab
Smooth muscle antibody
Thyroid hormone
Antiviral therapy
Arthritis
Autoimmune disease
Autoimmune hemolytic anemia
Autoimmune hepatitis
Autoimmune thrombocytopenia
Autoimmune thyroiditis
B lymphocyte
Cd4+ t lymphocyte
Cell selection
Chronic diarrhea
Coombs positive hemolytic anemia
Cryoglobulinemia
Discoid lupus erythematosus
Enteritis
Gender
Gene expression
Gene mutation
Hashimoto disease
Hepatitis c
Hormone substitution
Human
Hyper igm syndrome
Hypothyroidism
Immunoglobulin m deficiency
Infection
Interstitial pneumonia
Liver injury
Lymphoproliferative disease
Multiple sclerosis
Nephritis
Nonhuman
Plasmapheresis
Primary biliary cirrhosis
Review
Rheumatoid arthritis
Stem cell transplantation
Systemic lupus erythematosus
X chromosome
Autoimmune diseases
B-lymphocytes
Female
Humans
Hyper-igm immunodeficiency syndrome
Immunoglobulin m
Male
Sex factors
Autoimmune disease
Autoimmune hemolytic anemia
Cryoglobulinemia
Immunoglobulin m
Multiple sclerosis
Primary biliary cirrhosis
xxx
Karyotype 47
Duarte-Rey, Carolina
Bogdanos, Dimitrios P.
Leung, Patrick S.C.
Anaya, Juan-Manuel
Gershwin, M. Eric
IgM predominance in autoimmune disease: Genetics and gender
description The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V.
format Artículo (Article)
author Duarte-Rey, Carolina
Bogdanos, Dimitrios P.
Leung, Patrick S.C.
Anaya, Juan-Manuel
Gershwin, M. Eric
author_facet Duarte-Rey, Carolina
Bogdanos, Dimitrios P.
Leung, Patrick S.C.
Anaya, Juan-Manuel
Gershwin, M. Eric
author_sort Duarte-Rey, Carolina
title IgM predominance in autoimmune disease: Genetics and gender
title_short IgM predominance in autoimmune disease: Genetics and gender
title_full IgM predominance in autoimmune disease: Genetics and gender
title_fullStr IgM predominance in autoimmune disease: Genetics and gender
title_full_unstemmed IgM predominance in autoimmune disease: Genetics and gender
title_sort igm predominance in autoimmune disease: genetics and gender
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/23177
https://doi.org/10.1016/j.autrev.2011.12.001
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score 12,111491