IgM predominance in autoimmune disease: Genetics and gender
The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations...
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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2012
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23177 https://doi.org/10.1016/j.autrev.2011.12.001 |
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ir-10336-231772022-05-02T12:37:13Z IgM predominance in autoimmune disease: Genetics and gender Duarte-Rey, Carolina Bogdanos, Dimitrios P. Leung, Patrick S.C. Anaya, Juan-Manuel Gershwin, M. Eric Activation induced cytidine deaminase Alpha interferon Antinuclear antibody Antivirus agent Cd40 antigen Cd40 ligand Complement component c3b I kappa b kinase gamma Immunoglobulin Immunoglobulin m Rheumatoid factor Rituximab Smooth muscle antibody Thyroid hormone Antiviral therapy Arthritis Autoimmune disease Autoimmune hemolytic anemia Autoimmune hepatitis Autoimmune thrombocytopenia Autoimmune thyroiditis B lymphocyte Cd4+ t lymphocyte Cell selection Chronic diarrhea Coombs positive hemolytic anemia Cryoglobulinemia Discoid lupus erythematosus Enteritis Gender Gene expression Gene mutation Hashimoto disease Hepatitis c Hormone substitution Human Hyper igm syndrome Hypothyroidism Immunoglobulin m deficiency Infection Interstitial pneumonia Liver injury Lymphoproliferative disease Multiple sclerosis Nephritis Nonhuman Plasmapheresis Primary biliary cirrhosis Review Rheumatoid arthritis Stem cell transplantation Systemic lupus erythematosus X chromosome Autoimmune diseases B-lymphocytes Female Humans Hyper-igm immunodeficiency syndrome Immunoglobulin m Male Sex factors Autoimmune disease Autoimmune hemolytic anemia Cryoglobulinemia Immunoglobulin m Multiple sclerosis Primary biliary cirrhosis xxx Karyotype 47 The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V. 2012 2020-05-26T00:00:12Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15689972 https://repository.urosario.edu.co/handle/10336/23177 https://doi.org/10.1016/j.autrev.2011.12.001 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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DSpace |
| language |
Inglés (English) |
| topic |
Activation induced cytidine deaminase Alpha interferon Antinuclear antibody Antivirus agent Cd40 antigen Cd40 ligand Complement component c3b I kappa b kinase gamma Immunoglobulin Immunoglobulin m Rheumatoid factor Rituximab Smooth muscle antibody Thyroid hormone Antiviral therapy Arthritis Autoimmune disease Autoimmune hemolytic anemia Autoimmune hepatitis Autoimmune thrombocytopenia Autoimmune thyroiditis B lymphocyte Cd4+ t lymphocyte Cell selection Chronic diarrhea Coombs positive hemolytic anemia Cryoglobulinemia Discoid lupus erythematosus Enteritis Gender Gene expression Gene mutation Hashimoto disease Hepatitis c Hormone substitution Human Hyper igm syndrome Hypothyroidism Immunoglobulin m deficiency Infection Interstitial pneumonia Liver injury Lymphoproliferative disease Multiple sclerosis Nephritis Nonhuman Plasmapheresis Primary biliary cirrhosis Review Rheumatoid arthritis Stem cell transplantation Systemic lupus erythematosus X chromosome Autoimmune diseases B-lymphocytes Female Humans Hyper-igm immunodeficiency syndrome Immunoglobulin m Male Sex factors Autoimmune disease Autoimmune hemolytic anemia Cryoglobulinemia Immunoglobulin m Multiple sclerosis Primary biliary cirrhosis xxx Karyotype 47 |
| spellingShingle |
Activation induced cytidine deaminase Alpha interferon Antinuclear antibody Antivirus agent Cd40 antigen Cd40 ligand Complement component c3b I kappa b kinase gamma Immunoglobulin Immunoglobulin m Rheumatoid factor Rituximab Smooth muscle antibody Thyroid hormone Antiviral therapy Arthritis Autoimmune disease Autoimmune hemolytic anemia Autoimmune hepatitis Autoimmune thrombocytopenia Autoimmune thyroiditis B lymphocyte Cd4+ t lymphocyte Cell selection Chronic diarrhea Coombs positive hemolytic anemia Cryoglobulinemia Discoid lupus erythematosus Enteritis Gender Gene expression Gene mutation Hashimoto disease Hepatitis c Hormone substitution Human Hyper igm syndrome Hypothyroidism Immunoglobulin m deficiency Infection Interstitial pneumonia Liver injury Lymphoproliferative disease Multiple sclerosis Nephritis Nonhuman Plasmapheresis Primary biliary cirrhosis Review Rheumatoid arthritis Stem cell transplantation Systemic lupus erythematosus X chromosome Autoimmune diseases B-lymphocytes Female Humans Hyper-igm immunodeficiency syndrome Immunoglobulin m Male Sex factors Autoimmune disease Autoimmune hemolytic anemia Cryoglobulinemia Immunoglobulin m Multiple sclerosis Primary biliary cirrhosis xxx Karyotype 47 Duarte-Rey, Carolina Bogdanos, Dimitrios P. Leung, Patrick S.C. Anaya, Juan-Manuel Gershwin, M. Eric IgM predominance in autoimmune disease: Genetics and gender |
| description |
The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V. |
| format |
Artículo (Article) |
| author |
Duarte-Rey, Carolina Bogdanos, Dimitrios P. Leung, Patrick S.C. Anaya, Juan-Manuel Gershwin, M. Eric |
| author_facet |
Duarte-Rey, Carolina Bogdanos, Dimitrios P. Leung, Patrick S.C. Anaya, Juan-Manuel Gershwin, M. Eric |
| author_sort |
Duarte-Rey, Carolina |
| title |
IgM predominance in autoimmune disease: Genetics and gender |
| title_short |
IgM predominance in autoimmune disease: Genetics and gender |
| title_full |
IgM predominance in autoimmune disease: Genetics and gender |
| title_fullStr |
IgM predominance in autoimmune disease: Genetics and gender |
| title_full_unstemmed |
IgM predominance in autoimmune disease: Genetics and gender |
| title_sort |
igm predominance in autoimmune disease: genetics and gender |
| publishDate |
2012 |
| url |
https://repository.urosario.edu.co/handle/10336/23177 https://doi.org/10.1016/j.autrev.2011.12.001 |
| _version_ |
1740172705162854400 |
| score |
12,111491 |