Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review

Haematological alterations are common in patients with systemic lupus erythematosus (SLE). These haematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The compromise in coagulation is associated with thrombotic manifestations. Risk facto...

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Autores Principales: Reina Ávila M.F., Saza Mejía L.M., Guarnizo Zuccardi P.D.R., Rengifo L., Garcés Sterling S.P.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Asociacion Colombiana de Reumatologia 2019
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23063
https://doi.org/10.1016/j.rcreu.2019.01.002
id ir-10336-23063
recordtype dspace
spelling ir-10336-230632022-05-02T12:37:20Z Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review Manifestaciones relacionadas con alteraciones en la coagulación en lupus eritematoso sistémico de inicio juvenil. Reporte de casos y revisión de la literatura Reina Ávila M.F. Saza Mejía L.M. Guarnizo Zuccardi P.D.R. Rengifo L. Garcés Sterling S.P. Anti-phospholipid antibodies Bleeding complications Inhibitors Juvenile-onset systemic lupus erythematosus Thrombosis pathogenesis Haematological alterations are common in patients with systemic lupus erythematosus (SLE). These haematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The compromise in coagulation is associated with thrombotic manifestations. Risk factors associated with thrombosis have been described, such as the presence of elevated levels of homocysteine, acquired deficit of protein S, protein C, and antithrombin. However, the haemorrhagic diathesis has also been described at a lower frequency and related to the acquired deficiency of coagulation factors caused by the development of autoantibodies directed against coagulation factors. The cases are presented of 3 patients with juvenile SLE with unusual haematological manifestations, as well as a review of the literature in relation to them. The haematological manifestations in juvenile SLE are not only related to alterations in cell lines, vascular thrombosis and bleeding disorders should also be suspected. Early diagnosis and treatment reduces morbidity and mortality related to this type of manifestations. © 2019 Asociación Colombiana de Reumatología 2019 2020-05-25T23:59:32Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 01218123 20279000 https://repository.urosario.edu.co/handle/10336/23063 https://doi.org/10.1016/j.rcreu.2019.01.002 eng info:eu-repo/semantics/openAccess application/pdf Asociacion Colombiana de Reumatologia instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Anti-phospholipid antibodies
Bleeding complications
Inhibitors
Juvenile-onset systemic lupus erythematosus
Thrombosis pathogenesis
spellingShingle Anti-phospholipid antibodies
Bleeding complications
Inhibitors
Juvenile-onset systemic lupus erythematosus
Thrombosis pathogenesis
Reina Ávila M.F.
Saza Mejía L.M.
Guarnizo Zuccardi P.D.R.
Rengifo L.
Garcés Sterling S.P.
Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
description Haematological alterations are common in patients with systemic lupus erythematosus (SLE). These haematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The compromise in coagulation is associated with thrombotic manifestations. Risk factors associated with thrombosis have been described, such as the presence of elevated levels of homocysteine, acquired deficit of protein S, protein C, and antithrombin. However, the haemorrhagic diathesis has also been described at a lower frequency and related to the acquired deficiency of coagulation factors caused by the development of autoantibodies directed against coagulation factors. The cases are presented of 3 patients with juvenile SLE with unusual haematological manifestations, as well as a review of the literature in relation to them. The haematological manifestations in juvenile SLE are not only related to alterations in cell lines, vascular thrombosis and bleeding disorders should also be suspected. Early diagnosis and treatment reduces morbidity and mortality related to this type of manifestations. © 2019 Asociación Colombiana de Reumatología
format Artículo (Article)
author Reina Ávila M.F.
Saza Mejía L.M.
Guarnizo Zuccardi P.D.R.
Rengifo L.
Garcés Sterling S.P.
author_facet Reina Ávila M.F.
Saza Mejía L.M.
Guarnizo Zuccardi P.D.R.
Rengifo L.
Garcés Sterling S.P.
author_sort Reina Ávila M.F.
title Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
title_short Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
title_full Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
title_fullStr Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
title_full_unstemmed Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
title_sort manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. case report and literature review
publisher Asociacion Colombiana de Reumatologia
publishDate 2019
url https://repository.urosario.edu.co/handle/10336/23063
https://doi.org/10.1016/j.rcreu.2019.01.002
_version_ 1740172936819507200
score 12,131701