Vista Equipo: Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease

Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease

Introduction and Objectives: Analysis of nocturnal basal impedance (IBNM) has been proposed as a way to increase accuracy of GERD diagnosis. Our objective was to evaluate the diagnostic performance of this test in a group of patients known to have GERD. Materials and methods: We included 123 individ...

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Autores Principales:	Pineda O. L.F., Galindo M. P., Borráez Segura B.A., Guio Rn A., Angarita Santos O., Arbeláez V., Arévalo L.F.
Formato:	Artículo (Article)
Lenguaje:	Español (Spanish)
Publicado:	Asociacion Colombiana de Gastroenterologia 2018
Materias:	Esophageal baseline impedance Gerd Heartburn Ph impedance monitoring ROC AUC
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/23030 https://doi.org/10.22516/25007440.287

id	ir-10336-23030
recordtype	dspace
spelling	ir-10336-230302022-05-02T12:37:21Z Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease Eficacia diagnóstica de la impedancia basal nocturna media, un nuevo parámetro para el estudio de la enfermedad por reflujo gastroesofágico Pineda O. L.F. Galindo M. P. Borráez Segura B.A. Guio Rn A. Angarita Santos O. Arbeláez V. Arévalo L.F. Esophageal baseline impedance Gerd Heartburn Ph impedance monitoring ROC AUC Introduction and Objectives: Analysis of nocturnal basal impedance (IBNM) has been proposed as a way to increase accuracy of GERD diagnosis. Our objective was to evaluate the diagnostic performance of this test in a group of patients known to have GERD. Materials and methods: We included 123 individuals: 58 with GERD and 65 healthy controls. They underwent consecutive pH-impedance monitoring between January 2015 and June 2017. All had undergone endoscopy in the 6 months prior to testing. Criteria used for diagnosis of GERD were abnormal acid exposure time (AET > 4.2%), pyrosis and/or regurgitation in the previous 6 months. We found 58 patients with GERD of whom 24 had erosive reflux disease (ERE) and 34 had non-erosive reflux disease (NERD). The remaining 65 were asymptomatic healthy controls with normal endoscopic results and pH impedance monitoring. A second observer who did not know the previous data measurements analyzed all pH impedance monitoring traces for IBMN. Statistical analysis included multiple Bonferroni tests for comparison between groups, linear regression for continuous variables, and receiver operating characteristic (ROC) curve analysis to find high performance IBNM values. The IBNM cutoff point was used for diagnostic precision parameters. Statistical significance was set at p less than 0.01, and 95% confidence intervals were used for all calculations. Results: IBNM measures were significantly lower for patients with ERE and NERD than for the control group (p less than 0.01). A negative correlation was observed between IBNM and acid exposure time values (r = 0.59, p = less than 0.001) and also between IBNM and number of reflux events (r = 0.37, p = less than 0.001). ROC curve analysis found that the area under the curve for IBNM was 0.941 (95% CI: 0.894-0.987), and the cutoff point with the highest efficiency was 1,102 ohms (sensitivity 98.5%, specificity 84.5%). Using this value ( less than 1.102), the IBNM had a sensitivity for detecting GERD of 91% (NERD 86% and ERE 100%) and a specificity of 98%. Conclusion: IBNM has high sensitivity and specificity for diagnosis of GERD. Addition of this test to conventional pH-impedance analysis and current methods for studying GERD can significantly improve our ability to diagnose this disease. © 2018 Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología. 2018 2020-05-25T23:59:21Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1209957 https://repository.urosario.edu.co/handle/10336/23030 https://doi.org/10.22516/25007440.287 spa info:eu-repo/semantics/openAccess application/pdf Asociacion Colombiana de Gastroenterologia instname:Universidad del Rosario
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Español (Spanish)
topic	Esophageal baseline impedance Gerd Heartburn Ph impedance monitoring ROC AUC
spellingShingle	Esophageal baseline impedance Gerd Heartburn Ph impedance monitoring ROC AUC Pineda O. L.F. Galindo M. P. Borráez Segura B.A. Guio Rn A. Angarita Santos O. Arbeláez V. Arévalo L.F. Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
description	Introduction and Objectives: Analysis of nocturnal basal impedance (IBNM) has been proposed as a way to increase accuracy of GERD diagnosis. Our objective was to evaluate the diagnostic performance of this test in a group of patients known to have GERD. Materials and methods: We included 123 individuals: 58 with GERD and 65 healthy controls. They underwent consecutive pH-impedance monitoring between January 2015 and June 2017. All had undergone endoscopy in the 6 months prior to testing. Criteria used for diagnosis of GERD were abnormal acid exposure time (AET > 4.2%), pyrosis and/or regurgitation in the previous 6 months. We found 58 patients with GERD of whom 24 had erosive reflux disease (ERE) and 34 had non-erosive reflux disease (NERD). The remaining 65 were asymptomatic healthy controls with normal endoscopic results and pH impedance monitoring. A second observer who did not know the previous data measurements analyzed all pH impedance monitoring traces for IBMN. Statistical analysis included multiple Bonferroni tests for comparison between groups, linear regression for continuous variables, and receiver operating characteristic (ROC) curve analysis to find high performance IBNM values. The IBNM cutoff point was used for diagnostic precision parameters. Statistical significance was set at p less than 0.01, and 95% confidence intervals were used for all calculations. Results: IBNM measures were significantly lower for patients with ERE and NERD than for the control group (p less than 0.01). A negative correlation was observed between IBNM and acid exposure time values (r = 0.59, p = less than 0.001) and also between IBNM and number of reflux events (r = 0.37, p = less than 0.001). ROC curve analysis found that the area under the curve for IBNM was 0.941 (95% CI: 0.894-0.987), and the cutoff point with the highest efficiency was 1,102 ohms (sensitivity 98.5%, specificity 84.5%). Using this value ( less than 1.102), the IBNM had a sensitivity for detecting GERD of 91% (NERD 86% and ERE 100%) and a specificity of 98%. Conclusion: IBNM has high sensitivity and specificity for diagnosis of GERD. Addition of this test to conventional pH-impedance analysis and current methods for studying GERD can significantly improve our ability to diagnose this disease. © 2018 Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología.
format	Artículo (Article)
author	Pineda O. L.F. Galindo M. P. Borráez Segura B.A. Guio Rn A. Angarita Santos O. Arbeláez V. Arévalo L.F.
author_facet	Pineda O. L.F. Galindo M. P. Borráez Segura B.A. Guio Rn A. Angarita Santos O. Arbeláez V. Arévalo L.F.
author_sort	Pineda O. L.F.
title	Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
title_short	Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
title_full	Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
title_fullStr	Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
title_full_unstemmed	Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
title_sort	diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease
publisher	Asociacion Colombiana de Gastroenterologia
publishDate	2018
url	https://repository.urosario.edu.co/handle/10336/23030 https://doi.org/10.22516/25007440.287
_version_	1740172523026251776
score	12,131701

Diagnostic efficacy of mean nocturnal basal impedance, a new parameter for the study of gastroesophageal reflux disease

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