Imagen de Portada

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ?1 in 1,0...

Descripción completa

Detalles Bibliográficos
Autores Principales: Liu, Ke, Kurien, Biji T, Zimmerman, Sarah L, Kaufman, Kenneth M, Taft, Diana H, Kottyan, Leah C, Lazaro, Sara, Weaver, Carrie A, Ice, John A, Adler, Adam J, Chodosh, James, Radfar, Lida, Rasmussen, Astrid, Stone, Donald U, Lewis, David M, Li, Shibo, Koelsch, Kristi A, Igoe, Ann, Talsania, Mitali, Kumar, Jay, Maier-Moore, Jacen S, Harris, Valerie M, Gopalakrishnan, Rajaram, Jonsson, Roland, Lessard, James A, Lu, Xianglan, Gottenberg, Jacques-Eric, Anaya, Juan-Manuel, Cunninghame-Graham, Deborah S, Huang, Andrew J W, Brennan, Michael T, Hughes, Pamela, Illei, Gabor G, Miceli-Richard, Corinne, Keystone, Edward C, Bykerk, Vivian P, Hirschfield, Gideon, Xie, Gang, Ng, Wan-Fai, Nordmark, Gunnel, Eriksson, Per, Omdal, Roald, Rhodus, Nelson L, Rischmueller, Maureen, Rohrer, Michael, Segal, Barbara M, Vyse, Timothy J, Wahren-Herlenius, Marie, Witte, Torsten, Pons-Estel, Bernardo, Alarcon-Riquelme, Marta E, Guthridge, Joel M, James, Judith A, Lessard, Christopher J, Kelly, Jennifer A, Thompson, Susan D, Gaffney, Patrick M, Montgomery, Courtney G, Edberg, Jeffrey C, Kimberly, Robert P, Alarcón, Graciela S, Langefeld, Carl L, Gilkeson, Gary S, Kamen, Diane L, Tsao, Betty P, McCune, W Joseph, Salmon, Jane E, Merrill, Joan T, Weisman, Michael H, Wallace, Daniel J, Utset, Tammy O, Bottinger, Erwin P, Amos, Christopher I, Siminovitch, Katherine A, Mariette, Xavier, Sivils, Kathy L, Harley, John B, Scofield, R Hal
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: John Wiley and Sons Inc. 2016
Materias:
Article
Autoimmune disease
Controlled study
Female
Fluorescence in situ hybridization
Gene dosage
Human
Live birth
Major clinical study
Polymerase chain reaction
Prevalence
Primary biliary cirrhosis
Priority journal
Quality control
Rheumatoid arthritis
Sarcoidosis
Sex
Single nucleotide polymorphism
Systemic lupus erythematosus
X chromosome
Autoimmune Diseases
Case control study
Sex chromosome aberration
Sex Chromosome Disorders of Sex Development
Sex ratio
Sjogren's Syndrome
Trisomy
Case-Control Studies
Gene Dosage
Humans
Sex Chromosome Aberrations
Sex Distribution
Rheumatoid
Systemic
Fluorescence
Biliary
XXX
X
Karyotype 47
Arthritis
Liver Cirrhosis
Lupus Erythematosus
Chromosomes
In Situ Hybridization
Acceso en línea:https://repository.urosario.edu.co/handle/10336/23022
https://doi.org/10.1002/art.39560

Internet

https://repository.urosario.edu.co/handle/10336/23022
https://doi.org/10.1002/art.39560

Ejemplares similares