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BMP15 c.-9C>G promoter sequence variant may contribute to the cause of non-syndromic premature ovarian failure

BMP15 has drawn particular attention in the pathophysiology of reproduction, as its mutations in mammalian species have been related to different reproductive phenotypes. In humans, BMP15 coding regions have been sequenced in large panels of women with premature ovarian failure (POF), but only some...

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Detalles Bibliográficos
Autores Principales: Fonseca-Mendoza, Dora Janeth, Laissue, Paul, Ortega-Recalde, Oscar, Esteban-Perez, Clara, Moreno-Ortiz, Harold, Patiño, Liliana Catherine, Bermúdez, Olga María, Ortiz, Angela María, Restrepo, Carlos M., Lucena, Elkin
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier Ltd 2014
Materias:
Bone morphogenetic protein 15
Transcription factor
Transcription factor pitx1
Unclassified drug
Homeobox protein pitx1
Luciferase
Paired box transcription factor
Adult
Allele
Animal tissue
Article
Binding site
Bioinformatics
Computer model
Controlled study
Female
Gene expression profiling
Genetic association
Human
Human cell
In vitro study
Luciferase assay
Mouse
Nonhuman
Nucleotide sequence
Pathogenesis
Premature ovarian failure
Promoter region
Protein binding
Reverse transcription polymerase chain reaction
Single nucleotide polymorphism
Transactivation
Animal
Biology
Chlorocebus aethiops
Cos 1 cell line
Genetic transcription
Genetic variability
Genetics
Metabolism
Mutation
Ovary
Phenotype
Transcription initiation
Alleles
Animals
Binding sites
Cercopithecus aethiops
Computational biology
Cos cells
Genetic variation
Humans
Luciferases
Mice
Paired box transcription factors
Primary ovarian insufficiency
Transcriptional activation
Bmp15
Female infertility
Pitx1
single nucleotide
genetic
human
Bmp15 protein
Polymorphism
Promoter regions
Transcription
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22924
https://doi.org/10.1016/j.rbmo.2014.07.018

Internet

https://repository.urosario.edu.co/handle/10336/22924
https://doi.org/10.1016/j.rbmo.2014.07.018

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