Screening for mutations of the FOXO4 gene in premature ovarian failure patients

FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant...

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Autores Principales: Fonseca-Mendoza, Dora Janeth, Restrepo, Carlos M., Laissue, Paul, Garzón, Eliana, Lakhal, Besma, Braham, Rim, Ojeda, Diego, Elghezal, Hatem, Saâd, Ali
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
dna
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22923
https://doi.org/10.1016/j.rbmo.2011.11.017
id ir-10336-22923
recordtype dspace
spelling ir-10336-229232022-05-02T12:37:14Z Screening for mutations of the FOXO4 gene in premature ovarian failure patients Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Laissue, Paul Garzón, Eliana Lakhal, Besma Braham, Rim Ojeda, Diego Elghezal, Hatem Saâd, Ali Foxo4 protein Transcription factor Unclassified drug Article Controlled study Dna flanking region Exon Female Female infertility Gene expression Gene mutation Genetic screening Genetic variability Human Major clinical study Nucleotide sequence Open reading frame Pathogenesis Polymerase chain reaction Premature ovarian failure Promoter region Sequence analysis Tunisia Adult Dna mutational analysis Female Gene frequency Humans Mutation Open reading frames Primary ovarian insufficiency Transcription factors Tunisia Female infertility Foxo4 Premature ovarian failure genetic dna Promoter regions Sequence analysis FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. 2012 2020-05-25T23:58:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14726483 14726491 https://repository.urosario.edu.co/handle/10336/22923 https://doi.org/10.1016/j.rbmo.2011.11.017 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Foxo4 protein
Transcription factor
Unclassified drug
Article
Controlled study
Dna flanking region
Exon
Female
Female infertility
Gene expression
Gene mutation
Genetic screening
Genetic variability
Human
Major clinical study
Nucleotide sequence
Open reading frame
Pathogenesis
Polymerase chain reaction
Premature ovarian failure
Promoter region
Sequence analysis
Tunisia
Adult
Dna mutational analysis
Female
Gene frequency
Humans
Mutation
Open reading frames
Primary ovarian insufficiency
Transcription factors
Tunisia
Female infertility
Foxo4
Premature ovarian failure
genetic
dna
Promoter regions
Sequence analysis
spellingShingle Foxo4 protein
Transcription factor
Unclassified drug
Article
Controlled study
Dna flanking region
Exon
Female
Female infertility
Gene expression
Gene mutation
Genetic screening
Genetic variability
Human
Major clinical study
Nucleotide sequence
Open reading frame
Pathogenesis
Polymerase chain reaction
Premature ovarian failure
Promoter region
Sequence analysis
Tunisia
Adult
Dna mutational analysis
Female
Gene frequency
Humans
Mutation
Open reading frames
Primary ovarian insufficiency
Transcription factors
Tunisia
Female infertility
Foxo4
Premature ovarian failure
genetic
dna
Promoter regions
Sequence analysis
Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Laissue, Paul
Garzón, Eliana
Lakhal, Besma
Braham, Rim
Ojeda, Diego
Elghezal, Hatem
Saâd, Ali
Screening for mutations of the FOXO4 gene in premature ovarian failure patients
description FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
format Artículo (Article)
author Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Laissue, Paul
Garzón, Eliana
Lakhal, Besma
Braham, Rim
Ojeda, Diego
Elghezal, Hatem
Saâd, Ali
author_facet Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Laissue, Paul
Garzón, Eliana
Lakhal, Besma
Braham, Rim
Ojeda, Diego
Elghezal, Hatem
Saâd, Ali
author_sort Fonseca-Mendoza, Dora Janeth
title Screening for mutations of the FOXO4 gene in premature ovarian failure patients
title_short Screening for mutations of the FOXO4 gene in premature ovarian failure patients
title_full Screening for mutations of the FOXO4 gene in premature ovarian failure patients
title_fullStr Screening for mutations of the FOXO4 gene in premature ovarian failure patients
title_full_unstemmed Screening for mutations of the FOXO4 gene in premature ovarian failure patients
title_sort screening for mutations of the foxo4 gene in premature ovarian failure patients
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/22923
https://doi.org/10.1016/j.rbmo.2011.11.017
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score 12,131701