Screening for mutations of the FOXO4 gene in premature ovarian failure patients
FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22923 https://doi.org/10.1016/j.rbmo.2011.11.017 |
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ir-10336-229232022-05-02T12:37:14Z Screening for mutations of the FOXO4 gene in premature ovarian failure patients Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Laissue, Paul Garzón, Eliana Lakhal, Besma Braham, Rim Ojeda, Diego Elghezal, Hatem Saâd, Ali Foxo4 protein Transcription factor Unclassified drug Article Controlled study Dna flanking region Exon Female Female infertility Gene expression Gene mutation Genetic screening Genetic variability Human Major clinical study Nucleotide sequence Open reading frame Pathogenesis Polymerase chain reaction Premature ovarian failure Promoter region Sequence analysis Tunisia Adult Dna mutational analysis Female Gene frequency Humans Mutation Open reading frames Primary ovarian insufficiency Transcription factors Tunisia Female infertility Foxo4 Premature ovarian failure genetic dna Promoter regions Sequence analysis FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. 2012 2020-05-25T23:58:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14726483 14726491 https://repository.urosario.edu.co/handle/10336/22923 https://doi.org/10.1016/j.rbmo.2011.11.017 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
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DSpace |
language |
Inglés (English) |
topic |
Foxo4 protein Transcription factor Unclassified drug Article Controlled study Dna flanking region Exon Female Female infertility Gene expression Gene mutation Genetic screening Genetic variability Human Major clinical study Nucleotide sequence Open reading frame Pathogenesis Polymerase chain reaction Premature ovarian failure Promoter region Sequence analysis Tunisia Adult Dna mutational analysis Female Gene frequency Humans Mutation Open reading frames Primary ovarian insufficiency Transcription factors Tunisia Female infertility Foxo4 Premature ovarian failure genetic dna Promoter regions Sequence analysis |
spellingShingle |
Foxo4 protein Transcription factor Unclassified drug Article Controlled study Dna flanking region Exon Female Female infertility Gene expression Gene mutation Genetic screening Genetic variability Human Major clinical study Nucleotide sequence Open reading frame Pathogenesis Polymerase chain reaction Premature ovarian failure Promoter region Sequence analysis Tunisia Adult Dna mutational analysis Female Gene frequency Humans Mutation Open reading frames Primary ovarian insufficiency Transcription factors Tunisia Female infertility Foxo4 Premature ovarian failure genetic dna Promoter regions Sequence analysis Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Laissue, Paul Garzón, Eliana Lakhal, Besma Braham, Rim Ojeda, Diego Elghezal, Hatem Saâd, Ali Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
description |
FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
format |
Artículo (Article) |
author |
Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Laissue, Paul Garzón, Eliana Lakhal, Besma Braham, Rim Ojeda, Diego Elghezal, Hatem Saâd, Ali |
author_facet |
Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Laissue, Paul Garzón, Eliana Lakhal, Besma Braham, Rim Ojeda, Diego Elghezal, Hatem Saâd, Ali |
author_sort |
Fonseca-Mendoza, Dora Janeth |
title |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
title_short |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
title_full |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
title_fullStr |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
title_full_unstemmed |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients |
title_sort |
screening for mutations of the foxo4 gene in premature ovarian failure patients |
publishDate |
2012 |
url |
https://repository.urosario.edu.co/handle/10336/22923 https://doi.org/10.1016/j.rbmo.2011.11.017 |
_version_ |
1740172830448812032 |
score |
12,131701 |