The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator pr...

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Autores Principales: Misas E., Escandón P., McEwen J.G., Clay O.K.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Blackwell Publishing Ltd 2019
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22895
https://doi.org/10.1002/pro.3727
id ir-10336-22895
recordtype dspace
spelling ir-10336-228952022-05-02T12:37:19Z The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris Misas E. Escandón P. McEwen J.G. Clay O.K. Regulator protein Single stranded dna binding protein Transcription factor Article Candida auris Drug resistance Fungal virulence Nonhuman Priority journal Protein domain Protein structure Structure analysis Transcription initiation Transcription regulation Activation and repression domains Amphotericin b Antifungal resistance mechanisms Candida Filamentation in fungi Flocculence Lufs domain Single nucleotide polymorphisms Transcription factors Whole-genome sequence comparisons The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society 2019 2020-05-25T23:58:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 9618368 https://repository.urosario.edu.co/handle/10336/22895 https://doi.org/10.1002/pro.3727 eng info:eu-repo/semantics/openAccess application/pdf Blackwell Publishing Ltd instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Regulator protein
Single stranded dna binding protein
Transcription factor
Article
Candida auris
Drug resistance
Fungal virulence
Nonhuman
Priority journal
Protein domain
Protein structure
Structure analysis
Transcription initiation
Transcription regulation
Activation and repression domains
Amphotericin b
Antifungal resistance mechanisms
Candida
Filamentation in fungi
Flocculence
Lufs domain
Single nucleotide polymorphisms
Transcription factors
Whole-genome sequence comparisons
spellingShingle Regulator protein
Single stranded dna binding protein
Transcription factor
Article
Candida auris
Drug resistance
Fungal virulence
Nonhuman
Priority journal
Protein domain
Protein structure
Structure analysis
Transcription initiation
Transcription regulation
Activation and repression domains
Amphotericin b
Antifungal resistance mechanisms
Candida
Filamentation in fungi
Flocculence
Lufs domain
Single nucleotide polymorphisms
Transcription factors
Whole-genome sequence comparisons
Misas E.
Escandón P.
McEwen J.G.
Clay O.K.
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
description The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society
format Artículo (Article)
author Misas E.
Escandón P.
McEwen J.G.
Clay O.K.
author_facet Misas E.
Escandón P.
McEwen J.G.
Clay O.K.
author_sort Misas E.
title The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
title_short The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
title_full The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
title_fullStr The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
title_full_unstemmed The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
title_sort lufs domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen candida auris
publisher Blackwell Publishing Ltd
publishDate 2019
url https://repository.urosario.edu.co/handle/10336/22895
https://doi.org/10.1002/pro.3727
_version_ 1740173028602413056
score 12,131701