The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator pr...
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Blackwell Publishing Ltd
2019
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22895 https://doi.org/10.1002/pro.3727 |
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ir-10336-228952022-05-02T12:37:19Z The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris Misas E. Escandón P. McEwen J.G. Clay O.K. Regulator protein Single stranded dna binding protein Transcription factor Article Candida auris Drug resistance Fungal virulence Nonhuman Priority journal Protein domain Protein structure Structure analysis Transcription initiation Transcription regulation Activation and repression domains Amphotericin b Antifungal resistance mechanisms Candida Filamentation in fungi Flocculence Lufs domain Single nucleotide polymorphisms Transcription factors Whole-genome sequence comparisons The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society 2019 2020-05-25T23:58:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 9618368 https://repository.urosario.edu.co/handle/10336/22895 https://doi.org/10.1002/pro.3727 eng info:eu-repo/semantics/openAccess application/pdf Blackwell Publishing Ltd instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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language |
Inglés (English) |
topic |
Regulator protein Single stranded dna binding protein Transcription factor Article Candida auris Drug resistance Fungal virulence Nonhuman Priority journal Protein domain Protein structure Structure analysis Transcription initiation Transcription regulation Activation and repression domains Amphotericin b Antifungal resistance mechanisms Candida Filamentation in fungi Flocculence Lufs domain Single nucleotide polymorphisms Transcription factors Whole-genome sequence comparisons |
spellingShingle |
Regulator protein Single stranded dna binding protein Transcription factor Article Candida auris Drug resistance Fungal virulence Nonhuman Priority journal Protein domain Protein structure Structure analysis Transcription initiation Transcription regulation Activation and repression domains Amphotericin b Antifungal resistance mechanisms Candida Filamentation in fungi Flocculence Lufs domain Single nucleotide polymorphisms Transcription factors Whole-genome sequence comparisons Misas E. Escandón P. McEwen J.G. Clay O.K. The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
description |
The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society |
format |
Artículo (Article) |
author |
Misas E. Escandón P. McEwen J.G. Clay O.K. |
author_facet |
Misas E. Escandón P. McEwen J.G. Clay O.K. |
author_sort |
Misas E. |
title |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
title_short |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
title_full |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
title_fullStr |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
title_full_unstemmed |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
title_sort |
lufs domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen candida auris |
publisher |
Blackwell Publishing Ltd |
publishDate |
2019 |
url |
https://repository.urosario.edu.co/handle/10336/22895 https://doi.org/10.1002/pro.3727 |
_version_ |
1740173028602413056 |
score |
12,131701 |