The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease

Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer&...

Descripción completa

Detalles Bibliográficos
Autores Principales: Torres-Berrio A., Nava-Mesa, Mauricio O.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier Inc. 2019
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22887
https://doi.org/10.1016/j.pnpbp.2018.08.011
id ir-10336-22887
recordtype dspace
spelling ir-10336-228872022-05-02T12:37:16Z The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease Torres-Berrio A. Nava-Mesa, Mauricio O. Opiate Opiate receptor Opiate peptide Acute stress Adrenergic system Alzheimer disease Brain region Chronic stress Cognition Emotional disorder Human Hypothalamus hypophysis adrenal system Memory disorder Nonhuman Posttraumatic stress disorder Review Stress Symptomatology Alzheimer disease Animal Complication Limbic system Memory disorder Mental stress Metabolism Pathology Alzheimer disease Animals Humans Limbic system Memory disorders Opioid peptides Memory Neuropsychiatric stress disorders Opioid system Stress psychological Stress Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing. In this context, it is possible that stress-induced memory disorders may be attributed to alterations in the interaction between the neuroendocrine stress system and the opioid system. In this review, we: (1) describe the effects of acute and chronic stress on memory, and the modulatory role of the opioid system, (2) discuss the contribution of the opioid system to the pathophysiology of PTSD and AD, and (3) present evidence of current and potential therapies that target the opioid receptors to treat PTSD- and AD-associated symptoms. © 2018 The Authors 2019 2020-05-25T23:58:34Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2785846 https://repository.urosario.edu.co/handle/10336/22887 https://doi.org/10.1016/j.pnpbp.2018.08.011 eng info:eu-repo/semantics/openAccess application/pdf Elsevier Inc. instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Opiate
Opiate receptor
Opiate peptide
Acute stress
Adrenergic system
Alzheimer disease
Brain region
Chronic stress
Cognition
Emotional disorder
Human
Hypothalamus hypophysis adrenal system
Memory disorder
Nonhuman
Posttraumatic stress disorder
Review
Stress
Symptomatology
Alzheimer disease
Animal
Complication
Limbic system
Memory disorder
Mental stress
Metabolism
Pathology
Alzheimer disease
Animals
Humans
Limbic system
Memory disorders
Opioid peptides
Memory
Neuropsychiatric stress disorders
Opioid system
Stress
psychological
Stress
spellingShingle Opiate
Opiate receptor
Opiate peptide
Acute stress
Adrenergic system
Alzheimer disease
Brain region
Chronic stress
Cognition
Emotional disorder
Human
Hypothalamus hypophysis adrenal system
Memory disorder
Nonhuman
Posttraumatic stress disorder
Review
Stress
Symptomatology
Alzheimer disease
Animal
Complication
Limbic system
Memory disorder
Mental stress
Metabolism
Pathology
Alzheimer disease
Animals
Humans
Limbic system
Memory disorders
Opioid peptides
Memory
Neuropsychiatric stress disorders
Opioid system
Stress
psychological
Stress
Torres-Berrio A.
Nava-Mesa, Mauricio O.
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
description Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing. In this context, it is possible that stress-induced memory disorders may be attributed to alterations in the interaction between the neuroendocrine stress system and the opioid system. In this review, we: (1) describe the effects of acute and chronic stress on memory, and the modulatory role of the opioid system, (2) discuss the contribution of the opioid system to the pathophysiology of PTSD and AD, and (3) present evidence of current and potential therapies that target the opioid receptors to treat PTSD- and AD-associated symptoms. © 2018 The Authors
format Artículo (Article)
author Torres-Berrio A.
Nava-Mesa, Mauricio O.
author_facet Torres-Berrio A.
Nava-Mesa, Mauricio O.
author_sort Torres-Berrio A.
title The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
title_short The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
title_full The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
title_fullStr The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
title_full_unstemmed The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
title_sort opioid system in stress-induced memory disorders: from basic mechanisms to clinical implications in post-traumatic stress disorder and alzheimer's disease
publisher Elsevier Inc.
publishDate 2019
url https://repository.urosario.edu.co/handle/10336/22887
https://doi.org/10.1016/j.pnpbp.2018.08.011
_version_ 1740172403537870848
score 12,131701