The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer&...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22887 https://doi.org/10.1016/j.pnpbp.2018.08.011 |
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ir-10336-228872022-05-02T12:37:16Z The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease Torres-Berrio A. Nava-Mesa, Mauricio O. Opiate Opiate receptor Opiate peptide Acute stress Adrenergic system Alzheimer disease Brain region Chronic stress Cognition Emotional disorder Human Hypothalamus hypophysis adrenal system Memory disorder Nonhuman Posttraumatic stress disorder Review Stress Symptomatology Alzheimer disease Animal Complication Limbic system Memory disorder Mental stress Metabolism Pathology Alzheimer disease Animals Humans Limbic system Memory disorders Opioid peptides Memory Neuropsychiatric stress disorders Opioid system Stress psychological Stress Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing. In this context, it is possible that stress-induced memory disorders may be attributed to alterations in the interaction between the neuroendocrine stress system and the opioid system. In this review, we: (1) describe the effects of acute and chronic stress on memory, and the modulatory role of the opioid system, (2) discuss the contribution of the opioid system to the pathophysiology of PTSD and AD, and (3) present evidence of current and potential therapies that target the opioid receptors to treat PTSD- and AD-associated symptoms. © 2018 The Authors 2019 2020-05-25T23:58:34Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2785846 https://repository.urosario.edu.co/handle/10336/22887 https://doi.org/10.1016/j.pnpbp.2018.08.011 eng info:eu-repo/semantics/openAccess application/pdf Elsevier Inc. instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Opiate Opiate receptor Opiate peptide Acute stress Adrenergic system Alzheimer disease Brain region Chronic stress Cognition Emotional disorder Human Hypothalamus hypophysis adrenal system Memory disorder Nonhuman Posttraumatic stress disorder Review Stress Symptomatology Alzheimer disease Animal Complication Limbic system Memory disorder Mental stress Metabolism Pathology Alzheimer disease Animals Humans Limbic system Memory disorders Opioid peptides Memory Neuropsychiatric stress disorders Opioid system Stress psychological Stress |
spellingShingle |
Opiate Opiate receptor Opiate peptide Acute stress Adrenergic system Alzheimer disease Brain region Chronic stress Cognition Emotional disorder Human Hypothalamus hypophysis adrenal system Memory disorder Nonhuman Posttraumatic stress disorder Review Stress Symptomatology Alzheimer disease Animal Complication Limbic system Memory disorder Mental stress Metabolism Pathology Alzheimer disease Animals Humans Limbic system Memory disorders Opioid peptides Memory Neuropsychiatric stress disorders Opioid system Stress psychological Stress Torres-Berrio A. Nava-Mesa, Mauricio O. The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
description |
Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing. In this context, it is possible that stress-induced memory disorders may be attributed to alterations in the interaction between the neuroendocrine stress system and the opioid system. In this review, we: (1) describe the effects of acute and chronic stress on memory, and the modulatory role of the opioid system, (2) discuss the contribution of the opioid system to the pathophysiology of PTSD and AD, and (3) present evidence of current and potential therapies that target the opioid receptors to treat PTSD- and AD-associated symptoms. © 2018 The Authors |
format |
Artículo (Article) |
author |
Torres-Berrio A. Nava-Mesa, Mauricio O. |
author_facet |
Torres-Berrio A. Nava-Mesa, Mauricio O. |
author_sort |
Torres-Berrio A. |
title |
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
title_short |
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
title_full |
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
title_fullStr |
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
title_full_unstemmed |
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease |
title_sort |
opioid system in stress-induced memory disorders: from basic mechanisms to clinical implications in post-traumatic stress disorder and alzheimer's disease |
publisher |
Elsevier Inc. |
publishDate |
2019 |
url |
https://repository.urosario.edu.co/handle/10336/22887 https://doi.org/10.1016/j.pnpbp.2018.08.011 |
_version_ |
1740172403537870848 |
score |
12,131701 |