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A pharmacogenomic dissection of a Rosuvastatin-induced rhabdomyolysis case evokes the polygenic nature of adverse drug reactions

Rosuvastatin, is a widely-used statin for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Although rosuvastatin is well tolerated, about 3/10.000 patients can suffer severe myopathy. Rhabdomyolysis is a severe medical condition that causes injury to the skeletal...

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Detalles Bibliográficos
Autores Principales: Calderon-Ospina, Carlos-Alberto, Fonseca-Mendoza, Dora Janeth, Hernández-Sómerson, Mario, García, Ana María, Mejia, Adriana, Tamayo-Agudelo, Caroll, Laissue, Paul
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Dove Medical Press Ltd 2020
Materias:
Acetylsalicylic acid
Aminotransferase
Antihyperkalemic agent
Carvedilol
Creatine kinase
Creatinine
Cytochrome p450 2c19
Ezetimibe
Insulin detemir
Linagliptin
Losartan
Obscurin
Rosuvastatin
Ticagrelor
Abdominal distension
Abdominal pain
Abnormal urine composition
Aged
Article
Case report
Chronic kidney failure
Clinical article
Congestive cardiomyopathy
Coronary artery disease
Cyp2c19 gene
Dark urine
Dehydration
Drug induced disease
Drug metabolism
Drug safety
Electromyography
Emergency ward
Eyelid edema
Female
Gene
Gene frequency
Genetic association
Genetic variability
Heart left ventricle ejection fraction
Heart muscle revascularization
Hemodialysis
Hospital admission
Hospital discharge
Human
Human tissue
Hyperkalemia
Hyperphosphatemia
Hypertension
Hypocalcemia
Hyponatremia
Hypotension
Intervention study
Leukocytosis
Limb pain
Metabolic acidosis
Muscle biopsy
Myoglobinuria
Non insulin dependent diabetes mellitus
Npc1l1 gene
Obscn gene
Pharmacogenomics
Phase 1 clinical trial
Physical examination
Polymerase chain reaction
Pyelonephritis
Rhabdomyolysis
Rosuvastatin induced rhabdomyolysis
Scoring system
Tachycardia
Urea nitrogen blood level
Urinalysis
Whole exome sequencing
Adverse drug reaction
Polymorphisms
Whole-exome sequencing
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22797
https://doi.org/10.2147/PGPM.S228709

Internet

https://repository.urosario.edu.co/handle/10336/22797
https://doi.org/10.2147/PGPM.S228709

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