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DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression

HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral oncoproteins E6 and E7 that target >150 cellular...

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Detalles Bibliográficos
Autores Principales: Perrard, Jerome, Meznad, Koceila, Paget-Bailly, Philippe, Dalstein, Veronique, Guenat, David, Mourareau, Celine, Clavel, Christine, Fauconnet, Sylvie, Baguet, Aurelie, Mougin, Christiane, Pretet, Jean-Luc, Morel, Adrien
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Spandidos Publications 2020
Materias:
Decitabine
Methyltransferase
Microrna 375
Protein e6
Protein e7
Protein p21
Protein p53
Small interfering rna
T box transcription factor
Article
Ca ski cell line
Carcinogenesis
Cervical cancer cell line
Chemoluminescence
Controlled study
Dna demethylation
Down regulation
Gene overexpression
Gene repression
Genetic transfection
Hela cell line
Human
Human cell
Human papillomavirus 16 infection
Human papillomavirus type 16
Immune dysregulation
Immunoblotting
Immunoprecipitation
Luciferase assay
Mcf-7 cell line
Mrna expression level
Papillomavirus infection
Protein expression
Protein expression level
Reverse transcription polymerase chain reaction
Rna extraction
Siha cell line
Upregulation
Uterine cervix cancer
Western blotting
5-aza-2'-deoxycytidine
Dna methyltransferase inhibitor
Epigenetic
Human papillomavirus-induced cancer
T-box
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22720
https://doi.org/10.3892/ol.2019.11158

Internet

https://repository.urosario.edu.co/handle/10336/22720
https://doi.org/10.3892/ol.2019.11158

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