Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder

Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral pathology characterized by distinct degrees of inattention, hyperactivity and impulsivity. Although ADHD etiology remains elusive, the ADRA2A candidate gene underlies a particular interest, since it participates in the prefr...

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Autores Principales: Castro, Taryn, Mateus, Heidi Eliana, Forero, Diego, Fonseca-Mendoza, Dora Janeth, Restrepo, Carlos M., Talero-Gutiérrez, Claudia, Velez-van-Meerbeke, Alberto, Laissue, Paul
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2013
Materias:
DNA
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22657
https://doi.org/10.1007/s10072-013-1569-4
id ir-10336-22657
recordtype dspace
spelling ir-10336-226572022-05-02T12:37:14Z Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder Castro, Taryn Mateus, Heidi Eliana Forero, Diego Fonseca-Mendoza, Dora Janeth Restrepo, Carlos M. Talero-Gutiérrez, Claudia Velez-van-Meerbeke, Alberto Laissue, Paul Alpha 2A adrenergic receptor Alpha 2a adrenergic receptor gene Article Attention deficit disorder Child Colombia Controlled study Female Gene Gene sequence Genetic code Genetic variability Human Major clinical study Male Promoter region School child Sequence analysis Single nucleotide polymorphism Wild type Attention Deficit Disorder with Hyperactivity Child Colombia Female Humans Male ADHD ADRA2A Attention deficit hyperactivity disorder Behavior Genetics Single Nucleotide DNA Adrenergic alpha-2 Polymorphism Receptors Sequence Analysis Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral pathology characterized by distinct degrees of inattention, hyperactivity and impulsivity. Although ADHD etiology remains elusive, the ADRA2A candidate gene underlies a particular interest, since it participates in the prefrontal cortex regulation of executive function. Three SNPs located on 5? and 3?UTR regions of the gene have been extensively explored but none of them have been definitely validated as a predisposition or a causative sequence variation. In this study, in order to determine whether ADRA2A non-synonymous sequence variants, resulting in biochemical modifications of the protein, are a common cause of the disease we sequenced the complete ADRA2A coding region in a panel of ADHD children of Colombian origin. We identified the c.1138 C>A (p.Arg380Arg) silent substitution. We conclude that ADRA2A non-synonymous sequence variants do not cause ADHD in our sample population. We cannot formerly discard a potential role of this gene during ADHD pathogenesis since only the coding region was analysed. We hope that these results will encourage further researchers to sequence the promoter and coding regions of ADRA2A in large panels of ADHD patients from distinct ethnical origins. © 2013 Springer-Verlag Italia. 2013 2020-05-25T23:57:23Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15901874 15903478 https://repository.urosario.edu.co/handle/10336/22657 https://doi.org/10.1007/s10072-013-1569-4 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Alpha 2A adrenergic receptor
Alpha 2a adrenergic receptor gene
Article
Attention deficit disorder
Child
Colombia
Controlled study
Female
Gene
Gene sequence
Genetic code
Genetic variability
Human
Major clinical study
Male
Promoter region
School child
Sequence analysis
Single nucleotide polymorphism
Wild type
Attention Deficit Disorder with Hyperactivity
Child
Colombia
Female
Humans
Male
ADHD
ADRA2A
Attention deficit hyperactivity disorder
Behavior
Genetics
Single Nucleotide
DNA
Adrenergic
alpha-2
Polymorphism
Receptors
Sequence Analysis
spellingShingle Alpha 2A adrenergic receptor
Alpha 2a adrenergic receptor gene
Article
Attention deficit disorder
Child
Colombia
Controlled study
Female
Gene
Gene sequence
Genetic code
Genetic variability
Human
Major clinical study
Male
Promoter region
School child
Sequence analysis
Single nucleotide polymorphism
Wild type
Attention Deficit Disorder with Hyperactivity
Child
Colombia
Female
Humans
Male
ADHD
ADRA2A
Attention deficit hyperactivity disorder
Behavior
Genetics
Single Nucleotide
DNA
Adrenergic
alpha-2
Polymorphism
Receptors
Sequence Analysis
Castro, Taryn
Mateus, Heidi Eliana
Forero, Diego
Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Talero-Gutiérrez, Claudia
Velez-van-Meerbeke, Alberto
Laissue, Paul
Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
description Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral pathology characterized by distinct degrees of inattention, hyperactivity and impulsivity. Although ADHD etiology remains elusive, the ADRA2A candidate gene underlies a particular interest, since it participates in the prefrontal cortex regulation of executive function. Three SNPs located on 5? and 3?UTR regions of the gene have been extensively explored but none of them have been definitely validated as a predisposition or a causative sequence variation. In this study, in order to determine whether ADRA2A non-synonymous sequence variants, resulting in biochemical modifications of the protein, are a common cause of the disease we sequenced the complete ADRA2A coding region in a panel of ADHD children of Colombian origin. We identified the c.1138 C>A (p.Arg380Arg) silent substitution. We conclude that ADRA2A non-synonymous sequence variants do not cause ADHD in our sample population. We cannot formerly discard a potential role of this gene during ADHD pathogenesis since only the coding region was analysed. We hope that these results will encourage further researchers to sequence the promoter and coding regions of ADRA2A in large panels of ADHD patients from distinct ethnical origins. © 2013 Springer-Verlag Italia.
format Artículo (Article)
author Castro, Taryn
Mateus, Heidi Eliana
Forero, Diego
Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Talero-Gutiérrez, Claudia
Velez-van-Meerbeke, Alberto
Laissue, Paul
author_facet Castro, Taryn
Mateus, Heidi Eliana
Forero, Diego
Fonseca-Mendoza, Dora Janeth
Restrepo, Carlos M.
Talero-Gutiérrez, Claudia
Velez-van-Meerbeke, Alberto
Laissue, Paul
author_sort Castro, Taryn
title Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
title_short Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
title_full Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
title_fullStr Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
title_full_unstemmed Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder
title_sort sequence analysis of the adra2a coding region in children affected by attention deficit hyperactivity disorder
publishDate 2013
url https://repository.urosario.edu.co/handle/10336/22657
https://doi.org/10.1007/s10072-013-1569-4
_version_ 1740172117405597696
score 12,131701