Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1?/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ageing r...
Autores Principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artículo (Article) |
Lenguaje: | Inglés (English) |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22646 https://doi.org/10.1038/nature19329 |