Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

"Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1?/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ag...

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Detalles Bibliográficos
Autores Principales: Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, Cesar, Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., Gyenis, Á., Pothof, J., Vijg, J., van Steeg, H., Hoeijmakers, J. H. J.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Nature Publishing Group 2016
Materias:
Dna
Mus
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22646
https://doi.org/10.1038/nature19329