Existencias: Transcriptional regulator PRDM12 is essential for human pain perception

Transcriptional regulator PRDM12 is essential for human pain perception

Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal. New therapeutic options...

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Autores Principales:	Chen, Ya-Chun, Auer-Grumbach, Michaela, Matsukawa, Shinya, Zitzelsberger, Manuela, Themistocleous, Andreas C, Strom, Tim M, Samara, Chrysanthi, Moore, Adrian W, Cho, Lily Ting-Yin, Young, Gareth T, Weiss, Caecilia, Schabhüttl, Maria, Stucka, Rolf, Schmid, Annina B, Parman, Yesim, Graul-Neumann, Luitgard, Heinritz, Wolfram, Passarge, Eberhard, Watson, Rosemarie M, Hertz, Jens Michael, Moog, Ute, Baumgartner, Manuela, Valente, Enza Maria, Pereira, Diego, Katona, Istvan, Dusl, Marina, Stendel, Claudia, Wieland, Thomas, Stafford, Fay, Reimann, Frank, von Au, Katja, Finke, Christian, Willems, Patrick J, Nahorski, Michael S, Shaikh, Samiha S, Carvalho, Ofélia P, Nicholas, Adeline K, Karbani, Gulshan, McAleer, Maeve A, Cilio, Maria Roberta, McHugh, John C, Murphy, Sinead M, Irvine, Alan D, Jensen, Uffe Birk, Windhager, Reinhard, Weis, Joachim, Bergmann, Carsten, Rautenstrauss, Bernd, Baets, Jonathan, De Jonghe, Peter, Reilly, Mary M, Kropatsch, Regina, Kurth, Ingo, Chrast, Roman, Michiue, Tatsuo, Bennett, David L H, Woods, C Geoffrey, Senderek, Jan, Restrepo, Carlos M.
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	Nature Publishing Group 2015
Materias:	Isoprotein Prdm12 protein Unclassified drug Carrier protein Nerve protein Animal cell Article Autonomic innervation Basement membrane Cell nucleus Cellular distribution Chromosome 9 Chronic pain Codon Congenital analgesia Cornea reflex Cytoplasm Differentiation Embryo Embryo development Heterozygote Histone methylation Histone modification Human In situ hybridization Missense mutation Nervous system development Neural crest cell Nociception Nonhuman Pain receptor Phenotype Point mutation Priority journal Protein expression Protein function Protein interaction Sensory nerve cell Sodium current Sural nerve Tissue injury Xenopus Animal Chlorocebus aethiops Consanguinity Cos 1 cell line Female Genetic association Genetics Male Metabolism Mutation Neuropathy Pedigree Single nucleotide polymorphism Xenopus laevis Animals Carrier proteins Cercopithecus aethiops Cos cells Genetic association studies Hereditary sensory and autonomic neuropathies Humans Nerve tissue proteins Neurogenesis Nociceptors Pain perception human congenital single nucleotide Pain insensitivity Polymorphism
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/22640 https://doi.org/10.1038/ng.3308

Internet

https://repository.urosario.edu.co/handle/10336/22640
https://doi.org/10.1038/ng.3308

Transcriptional regulator PRDM12 is essential for human pain perception

Internet

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