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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE. By fine mapping and genomic re-...

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Detalles Bibliográficos
Autores Principales: Adrianto I., Wen F., Templeton A., Wiley G., King J.B., Lessard C.J., Bates J.S., Hu Y., Kelly J.A., Kaufman K.M., Guthridge J.M., Alarcón-Riquelme M.E., Anaya, Juan-Manuel, Bae S.-C., Bang S.-Y., Boackle S.A., Brown E.E., Petri M.A., Gallant C., Ramsey-Goldman R., Reveille J.D., Vila L.M., Criswell L.A., Edberg J.C., Freedman B.I., Gregersen P.K., Gilkeson G.S., Jacob C.O., James J.A., Kamen D.L., Kimberly R.P., Martin J., Merrill J.T., Niewold T.B., Park S.-Y., Pons-Estel B.A., Scofield R.H., Stevens A.M., Tsao B.P., Vyse T.J., Langefeld C.D., Harley J.B., Moser K.L., Webb C.F., Humphrey M.B., Montgomery C.G., Gaffney P.M.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2011
Materias:
Immunoglobulin enhancer binding protein
Messenger rna
Protein subunit
Transcription factor
Tumor necrosis factor alpha inducible protein 3
Unclassified drug
African american
Asian
Chromosome 6
Chromosome analysis
Controlled study
Ethnicity
Gene deletion
Gene identification
Gene locus
Gene mapping
Genetic association
Genetic risk
Genetic susceptibility
Genetic variability
Genome analysis
Haplotype
Hispanic
Human
Nucleotide sequence
Priority journal
Promoter region
Protein expression
Review
Single nucleotide polymorphism
Systemic lupus erythematosus
Base sequence
Female
Haplotypes
Humans
Intracellular signaling peptides and proteins
Linkage disequilibrium
Male
Molecular sequence data
Nuclear proteins
single nucleotide
systemic
Lupus erythematosus
Polymorphism
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22638
https://doi.org/10.1038/ng.766

Internet

https://repository.urosario.edu.co/handle/10336/22638
https://doi.org/10.1038/ng.766

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