Existencias: DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, however, is highly rudimentary. Using Ercc1-defecti...

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Autores Principales:	Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G., Payan-Gomez, Cesar
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	Nature Publishing Group 2019
Materias:	1 phosphofructokinase Antimycin a1 Carbonyl cyanide 4 (trifluoromethoxy)phenylhydrazone Glucose 6 phosphate dehydrogenase Glucose transporter Glutathione Oligomycin Pentose phosphate Reduced nicotinamide adenine dinucleotide phosphate Rotenone Sugar phosphate Adenosine triphosphate Antioxidant Dna binding protein Dna excision repair protein ercc-5 Endonuclease Nicotinamide adenine dinucleotide phosphate Nuclear protein Transcription factor Aging Bioenergetics Buffering Dna Enzyme activity Metabolism Phosphate Redox conditions Stress analysis Ampk signaling Animal experiment Animal model Antioxidant activity Article Bioenergy Bioinformatics Cell isolation Cockayne syndrome Cycloaddition Dna damage Dna repair Dna transcription Down regulation Drug potentiation Enzyme metabolism Excision repair Female Flow cytometry Gene expression level Gene mutation Genomic instability Glycolysis High performance liquid chromatography Male Metabolic activity assay Metabolic flux analysis Mitochondrial respiration Mouse Nonhuman Nuclear reprogramming Oxygen consumption Pentose phosphate cycle Peritoneum Polymerase chain reaction Protein phosphorylation Redox stress Rna isolation Rna synthesis Signal transduction Skin biopsy Skin fibroblast Transcription coupled dna repair Upregulation Allosterism Animal Cytology Fibroblast Genetic transcription Genetics Knockout mouse Metabolomics Oxidation reduction reaction Physiology Skin Animalia Mus Allosteric regulation Animals Antioxidants Dna-binding proteins Endonucleases Fibroblasts Mice Nadp Nuclear proteins Oxidation-reduction Pentose phosphate pathway Transcription factors knockout mouse genetic Ercc1 protein Transcription
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/22636 https://doi.org/10.1038/s41467-019-12640-5

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https://repository.urosario.edu.co/handle/10336/22636
https://doi.org/10.1038/s41467-019-12640-5

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Internet

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