DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

"Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, however, is highly rudimentary. Using Ercc1-d...

Descripción completa

Detalles Bibliográficos
Autores Principales: Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Nature Publishing Group 2019
Materias:
Dna
Mus
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22636
https://doi.org/10.1038/s41467-019-12640-5