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Synthetic evaluation of standard and microwave-assisted solid phase peptide synthesis of a long chimeric peptide derived from four Plasmodium falciparum proteins

An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene glycol (PEG) resin. Similar synthetic difficulties...

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Detalles Bibliográficos
Autores Principales: Varela, Yahson F., Murcia, Magnolia Vanegas, Patarroyo, Manuel Elkin
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: MDPI AG 2018
Materias:
Peptide
Protozoal protein
Chemistry
Drug effect
Metabolism
Microwave radiation
Molecular weight
Plasmodium falciparum
Solid phase synthesis
Spectroscopy
Synthesis
Microwaves
Peptides
Protozoan proteins
Solid-phase synthesis techniques
Spectrum analysis
Chimeric peptide
Coupling
Fmoc protocol
Solid phase peptide synthesis
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22628
https://doi.org/10.3390/molecules23112877

Internet

https://repository.urosario.edu.co/handle/10336/22628
https://doi.org/10.3390/molecules23112877

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