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The PHF21B gene is associated with major depression and modulates the stress response

Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functio...

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Detalles Bibliográficos
Autores Principales: Wong, M-L, Arcos-Burgos, M, Liu, S, Vélez, J I, Yu, C, Baune, B T, Jawahar, M C, Arolt, V, Dannlowski, U, Chuah, A, Huttley, G A, Fogarty, R, Lewis, M D, Bornstein, S R, Licinio, J
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Nature Publishing Group 2017
Materias:
Glutamate receptor
Phd finger protein 21b
Transient receptor potential channel m2
Ubiquitin protein ligase
Unclassified drug
Adult
Aged
Animal experiment
Animal tissue
Article
Brain region
California
Chronic stress
Clinical trial (topic)
Cohort analysis
Controlled study
Disease severity
European
Gene expression
Gene locus
Gene ontology
Genetic association
Genetic variability
Genome-wide association study
Genotype environment interaction
Haplotype
Heritability
Hippocampus
Human
Immigrant
Immobilization stress
Innate immunity
Major clinical study
Major depression
Male
Mexican american
Molecular pathology
Nonhuman
Phf21b gene
Priority journal
Rat
Sensory perception test
Single nucleotide polymorphism
Stress
Trpm2 gene
Whole genome sequencing
Case control study
Caucasian
Female
Genetic predisposition
Genetics
Mental stress
Middle aged
Risk factor
Case-control studies
European continental ancestry group
Genetic predisposition to disease
Humans
Los angeles
Mexican americans
Risk factors
major
single nucleotide
psychological
Depressive disorder
Polymorphism
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22624
https://doi.org/10.1038/mp.2016.174

Internet

https://repository.urosario.edu.co/handle/10336/22624
https://doi.org/10.1038/mp.2016.174

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