Reproductive clonality in protozoan pathogens - Truth or artefact?

The debate around the frequency and importance of genetic exchange in parasitic protozoa is now several decades old. Recently, fresh assertions have been made that predominant clonal evolution explains the population structures of several key protozoan pathogens. Here, we present an alternative pers...

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Autores Principales: Ramírez, Juan David, Llewellyn, Martin S.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22613
https://doi.org/10.1111/mec.12872
id ir-10336-22613
recordtype dspace
spelling ir-10336-226132022-05-02T12:37:14Z Reproductive clonality in protozoan pathogens - Truth or artefact? Ramírez, Juan David Llewellyn, Martin S. Clonal evolution Clonal variation Evolution Gene exchange Genetic variability Genetics Giardia Physiology Protozoan pathogens Review Sexuality Toxoplasma Clonality Genetic exchange Protozoan pathogens Sexuality Biological evolution Clonal evolution Genetic variation Giardia Toxoplasma Clonality Genetic exchange Protozoan pathogens Sexuality The debate around the frequency and importance of genetic exchange in parasitic protozoa is now several decades old. Recently, fresh assertions have been made that predominant clonal evolution explains the population structures of several key protozoan pathogens. Here, we present an alternative perspective. On the assumption that much apparent clonality may be an artefact of inadequate sampling and study design, we review current research to define why sex might be so difficult to detect in protozoan parasite populations. In doing so, we contrast laboratory models of genetic exchange in parasitic protozoa with natural patterns of genetic diversity and consider the fitness advantage of sex at different evolutionary scales. We discuss approaches to improve the accuracy of efforts to characterize genetic exchange in the field. We also examine the implications of the first population genomic studies for the debate around sex and clonality in parasitic protozoa and discuss caveats for the future. © 2014 John Wiley and Sons Ltd. 2014 2020-05-25T23:57:08Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1365294X 09621083 https://repository.urosario.edu.co/handle/10336/22613 https://doi.org/10.1111/mec.12872 eng info:eu-repo/semantics/openAccess application/pdf Blackwell Publishing Ltd instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Clonal evolution
Clonal variation
Evolution
Gene exchange
Genetic variability
Genetics
Giardia
Physiology
Protozoan pathogens
Review
Sexuality
Toxoplasma
Clonality
Genetic exchange
Protozoan pathogens
Sexuality
Biological evolution
Clonal evolution
Genetic variation
Giardia
Toxoplasma
Clonality
Genetic exchange
Protozoan pathogens
Sexuality
spellingShingle Clonal evolution
Clonal variation
Evolution
Gene exchange
Genetic variability
Genetics
Giardia
Physiology
Protozoan pathogens
Review
Sexuality
Toxoplasma
Clonality
Genetic exchange
Protozoan pathogens
Sexuality
Biological evolution
Clonal evolution
Genetic variation
Giardia
Toxoplasma
Clonality
Genetic exchange
Protozoan pathogens
Sexuality
Ramírez, Juan David
Llewellyn, Martin S.
Reproductive clonality in protozoan pathogens - Truth or artefact?
description The debate around the frequency and importance of genetic exchange in parasitic protozoa is now several decades old. Recently, fresh assertions have been made that predominant clonal evolution explains the population structures of several key protozoan pathogens. Here, we present an alternative perspective. On the assumption that much apparent clonality may be an artefact of inadequate sampling and study design, we review current research to define why sex might be so difficult to detect in protozoan parasite populations. In doing so, we contrast laboratory models of genetic exchange in parasitic protozoa with natural patterns of genetic diversity and consider the fitness advantage of sex at different evolutionary scales. We discuss approaches to improve the accuracy of efforts to characterize genetic exchange in the field. We also examine the implications of the first population genomic studies for the debate around sex and clonality in parasitic protozoa and discuss caveats for the future. © 2014 John Wiley and Sons Ltd.
format Artículo (Article)
author Ramírez, Juan David
Llewellyn, Martin S.
author_facet Ramírez, Juan David
Llewellyn, Martin S.
author_sort Ramírez, Juan David
title Reproductive clonality in protozoan pathogens - Truth or artefact?
title_short Reproductive clonality in protozoan pathogens - Truth or artefact?
title_full Reproductive clonality in protozoan pathogens - Truth or artefact?
title_fullStr Reproductive clonality in protozoan pathogens - Truth or artefact?
title_full_unstemmed Reproductive clonality in protozoan pathogens - Truth or artefact?
title_sort reproductive clonality in protozoan pathogens - truth or artefact?
publisher Blackwell Publishing Ltd
publishDate 2014
url https://repository.urosario.edu.co/handle/10336/22613
https://doi.org/10.1111/mec.12872
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score 12,131701