The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distribut...
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BioMed Central Ltd.
2019
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22607 https://doi.org/10.1186/s12943-019-0938-x |
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ir-10336-226072021-06-11T03:53:08Z The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology Laissue, Paul Cisplatin Forkhead box protein m1 Forkhead transcription factor Oncoprotein Transcription factor foxo Transcription factor foxp3 Forkhead transcription factor Akt1 gene Akt2 gene Apoptosis Binding affinity Cancer cell Cancer diagnosis Cancer growth Cancer research Cell cycle g1 phase Cell cycle g2 phase Cell cycle m phase Cell cycle regulation Cell cycle s phase Cell proliferation Clinical research Colon carcinogenesis Colorectal cancer Crispr-cas9 system Dna binding Fox gene Foxm1 gene Foxo gene Foxp3 gene Gene editing Gene expression regulation Gene function Human Immunity Lymphocytic infiltration Nonhuman Pdpk1 gene Protein phosphorylation Regulatory t lymphocyte Review Science Transcription regulation Tumor microenvironment Tumor suppressor gene Animal Cell motion Colorectal tumor Genetics Pathology Prognosis Animals Cell movement Cell proliferation Colorectal neoplasms Forkhead transcription factors Humans Prognosis Colorectal cancer Forkhead transcription factors Molecular aetiology neoplastic Gene expression regulation Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. Several FOX gene subgroup transcriptional disturbances, affecting numerous complex molecular cascades, have been linked to a wide range of cancer types highlighting their potential usefulness as molecular biomarkers. At least 14 FOX subgroups have been related to CRC pathogenesis, thereby underlining their role for diagnosis, prognosis and treatment purposes. This manuscript aims to provide, for the first time, a comprehensive review of FOX genes' roles during CRC pathogenesis. The molecular and functional characteristics of most relevant FOX molecules (FOXO, FOXM1, FOXP3) have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis. Potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included. Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. © 2019 The Author(s). 2019 2020-05-25T23:57:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14764598 https://repository.urosario.edu.co/handle/10336/22607 https://doi.org/10.1186/s12943-019-0938-x eng info:eu-repo/semantics/openAccess application/pdf BioMed Central Ltd. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR |
| institution |
EdocUR - Universidad del Rosario |
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DSpace |
| language |
Inglés (English) |
| topic |
Cisplatin Forkhead box protein m1 Forkhead transcription factor Oncoprotein Transcription factor foxo Transcription factor foxp3 Forkhead transcription factor Akt1 gene Akt2 gene Apoptosis Binding affinity Cancer cell Cancer diagnosis Cancer growth Cancer research Cell cycle g1 phase Cell cycle g2 phase Cell cycle m phase Cell cycle regulation Cell cycle s phase Cell proliferation Clinical research Colon carcinogenesis Colorectal cancer Crispr-cas9 system Dna binding Fox gene Foxm1 gene Foxo gene Foxp3 gene Gene editing Gene expression regulation Gene function Human Immunity Lymphocytic infiltration Nonhuman Pdpk1 gene Protein phosphorylation Regulatory t lymphocyte Review Science Transcription regulation Tumor microenvironment Tumor suppressor gene Animal Cell motion Colorectal tumor Genetics Pathology Prognosis Animals Cell movement Cell proliferation Colorectal neoplasms Forkhead transcription factors Humans Prognosis Colorectal cancer Forkhead transcription factors Molecular aetiology neoplastic Gene expression regulation |
| spellingShingle |
Cisplatin Forkhead box protein m1 Forkhead transcription factor Oncoprotein Transcription factor foxo Transcription factor foxp3 Forkhead transcription factor Akt1 gene Akt2 gene Apoptosis Binding affinity Cancer cell Cancer diagnosis Cancer growth Cancer research Cell cycle g1 phase Cell cycle g2 phase Cell cycle m phase Cell cycle regulation Cell cycle s phase Cell proliferation Clinical research Colon carcinogenesis Colorectal cancer Crispr-cas9 system Dna binding Fox gene Foxm1 gene Foxo gene Foxp3 gene Gene editing Gene expression regulation Gene function Human Immunity Lymphocytic infiltration Nonhuman Pdpk1 gene Protein phosphorylation Regulatory t lymphocyte Review Science Transcription regulation Tumor microenvironment Tumor suppressor gene Animal Cell motion Colorectal tumor Genetics Pathology Prognosis Animals Cell movement Cell proliferation Colorectal neoplasms Forkhead transcription factors Humans Prognosis Colorectal cancer Forkhead transcription factors Molecular aetiology neoplastic Gene expression regulation Laissue, Paul The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| description |
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. Several FOX gene subgroup transcriptional disturbances, affecting numerous complex molecular cascades, have been linked to a wide range of cancer types highlighting their potential usefulness as molecular biomarkers. At least 14 FOX subgroups have been related to CRC pathogenesis, thereby underlining their role for diagnosis, prognosis and treatment purposes. This manuscript aims to provide, for the first time, a comprehensive review of FOX genes' roles during CRC pathogenesis. The molecular and functional characteristics of most relevant FOX molecules (FOXO, FOXM1, FOXP3) have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis. Potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included. Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. © 2019 The Author(s). |
| format |
Artículo (Article) |
| author |
Laissue, Paul |
| author_facet |
Laissue, Paul |
| author_sort |
Laissue, Paul |
| title |
The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| title_short |
The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| title_full |
The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| title_fullStr |
The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| title_full_unstemmed |
The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology |
| title_sort |
forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis 06 biological sciences 0604 genetics 11 medical and health sciences 1112 oncology and carcinogenesis 06 biological sciences 0601 biochemistry and cell biology |
| publisher |
BioMed Central Ltd. |
| publishDate |
2019 |
| url |
https://repository.urosario.edu.co/handle/10336/22607 https://doi.org/10.1186/s12943-019-0938-x |
| _version_ |
1702626585362825216 |
| score |
12,131701 |