Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude
This study reported the frequency of anesthetic overdose measured with the bispectral index in a high altitude city (Bogotá-Colombia, 2600 meters above sea level). We assembled a prospective cohort of patients. Preoperative variables were described, and 10 minutes after the surgical incision, bispec...
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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Wolters Kluwer Medknow Publications
2018
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22568 https://doi.org/10.4103/2045-9912.248265 |
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ir-10336-225682022-05-02T12:37:14Z Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude Giraldo, Juan C Acosta, Claudia Giraldo-Grueso, Manuel Anesthetic agent Sevoflurane Adult Age Altitude Article Bispectral index Clinical article Cohort analysis Colombia Drug intoxication Drug overdose Female General anesthesia Human Inhalation anesthesia Intraoperative awareness Male Mean alveolar concentration Mean arterial pressure Oxygen saturation Patient safety Priority journal Prospective study Respiratory tract parameters General anesthesia Drug overdose Biespectral index Mean alveolar concentration Altitude Inhalation Intraoperative awareness This study reported the frequency of anesthetic overdose measured with the bispectral index in a high altitude city (Bogotá-Colombia, 2600 meters above sea level). We assembled a prospective cohort of patients. Preoperative variables were described, and 10 minutes after the surgical incision, bispectral index, mean alveolar concentration, mean arterial pressure, and oxygen saturation were recorded. Bispectral index was classified as superficial (60), adequate (40-60), and deep (> 40). Mean alveolar concentration was classified as low ( less than 0.8), normal (0.8-1.2), and high (> 1.2). We included 50 patients. The mean age of the patients was 36.3 ± 13.5 years; 48% were male and 78% were categorized as ASA I. Mean values of mean alveolar concentration and bispectral index were 1.14 ± 0.18 and 38.66 ± 6.9, respectively. Frequency of anesthetic overdose measured with bispectral index was 54% and only 20% with mean alveolar concentration. In total, 78% of patients received normal mean alveolar concentration values, and among these patients, 49% had deep bispectral index levels and 51% were adequate. There was no correlation between mean alveolar concentration and bispectral index (Pearson r = 0.161, P = 0.246) or between bispectral index and mean arterial pressure (Pearson r = 0.367, P = 0.08). All patients older than 60 years exhibited deep bispectral index levels, and although we did not identify a correlation between age and bispectral index, a tendency was observed (Pearson r = -0.087, P = 0.538). Safe and effective anesthesia overdose could be a common phenomenon. Bispectral index-guided anesthesia could be a helpful and reliable tool in the assessment and prevention of anesthesia overdose at high altitude. The study was approved by the ethics committee of the Fundación Cardioinfantil-Instituto de cardiología, Bogota, Colombia (approved number: 312017). © 2019 Medical Gas Research Published by Wolters Kluwer - Medknow. 2018 2020-05-25T23:56:57Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 20459912 https://repository.urosario.edu.co/handle/10336/22568 https://doi.org/10.4103/2045-9912.248265 eng info:eu-repo/semantics/openAccess application/pdf Wolters Kluwer Medknow Publications instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Anesthetic agent Sevoflurane Adult Age Altitude Article Bispectral index Clinical article Cohort analysis Colombia Drug intoxication Drug overdose Female General anesthesia Human Inhalation anesthesia Intraoperative awareness Male Mean alveolar concentration Mean arterial pressure Oxygen saturation Patient safety Priority journal Prospective study Respiratory tract parameters General anesthesia Drug overdose Biespectral index Mean alveolar concentration Altitude Inhalation Intraoperative awareness |
| spellingShingle |
Anesthetic agent Sevoflurane Adult Age Altitude Article Bispectral index Clinical article Cohort analysis Colombia Drug intoxication Drug overdose Female General anesthesia Human Inhalation anesthesia Intraoperative awareness Male Mean alveolar concentration Mean arterial pressure Oxygen saturation Patient safety Priority journal Prospective study Respiratory tract parameters General anesthesia Drug overdose Biespectral index Mean alveolar concentration Altitude Inhalation Intraoperative awareness Giraldo, Juan C Acosta, Claudia Giraldo-Grueso, Manuel Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| description |
This study reported the frequency of anesthetic overdose measured with the bispectral index in a high altitude city (Bogotá-Colombia, 2600 meters above sea level). We assembled a prospective cohort of patients. Preoperative variables were described, and 10 minutes after the surgical incision, bispectral index, mean alveolar concentration, mean arterial pressure, and oxygen saturation were recorded. Bispectral index was classified as superficial (60), adequate (40-60), and deep (> 40). Mean alveolar concentration was classified as low ( less than 0.8), normal (0.8-1.2), and high (> 1.2). We included 50 patients. The mean age of the patients was 36.3 ± 13.5 years; 48% were male and 78% were categorized as ASA I. Mean values of mean alveolar concentration and bispectral index were 1.14 ± 0.18 and 38.66 ± 6.9, respectively. Frequency of anesthetic overdose measured with bispectral index was 54% and only 20% with mean alveolar concentration. In total, 78% of patients received normal mean alveolar concentration values, and among these patients, 49% had deep bispectral index levels and 51% were adequate. There was no correlation between mean alveolar concentration and bispectral index (Pearson r = 0.161, P = 0.246) or between bispectral index and mean arterial pressure (Pearson r = 0.367, P = 0.08). All patients older than 60 years exhibited deep bispectral index levels, and although we did not identify a correlation between age and bispectral index, a tendency was observed (Pearson r = -0.087, P = 0.538). Safe and effective anesthesia overdose could be a common phenomenon. Bispectral index-guided anesthesia could be a helpful and reliable tool in the assessment and prevention of anesthesia overdose at high altitude. The study was approved by the ethics committee of the Fundación Cardioinfantil-Instituto de cardiología, Bogota, Colombia (approved number: 312017). © 2019 Medical Gas Research Published by Wolters Kluwer - Medknow. |
| format |
Artículo (Article) |
| author |
Giraldo, Juan C Acosta, Claudia Giraldo-Grueso, Manuel |
| author_facet |
Giraldo, Juan C Acosta, Claudia Giraldo-Grueso, Manuel |
| author_sort |
Giraldo, Juan C |
| title |
Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| title_short |
Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| title_full |
Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| title_fullStr |
Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| title_full_unstemmed |
Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| title_sort |
frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2018 |
| url |
https://repository.urosario.edu.co/handle/10336/22568 https://doi.org/10.4103/2045-9912.248265 |
| _version_ |
1740173045252751360 |
| score |
12,131701 |