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Size polymorphism and low sequence diversity in the locus encoding the Plasmodium vivax rhoptry neck protein 4 (PvRON4) in Colombian isolates

Background: Designing a vaccine against Plasmodium vivax has focused on selecting antigens involved in invasion mechanisms that must have domains with low polymorphism for avoiding allele-specific immune responses. The rhoptry neck protein 4 (RON4) forms part of the tight junction, which is essentia...

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Detalles Bibliográficos
Autores Principales: Buitrago, Sindy P., Garzón-Ospina, Diego, Patarroyo, Manuel A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: BioMed Central Ltd. 2016
Materias:
Esterase
Rhoptry neck protein 4
Tight junction protein
Triacylglycerol lipase
Unclassified drug
Protozoal dna
Protozoal protein
Amino terminal sequence
Article
Carboxy terminal sequence
Colombia
Controlled study
Dna sequence
Gene
Genetic conservation
Genetic polymorphism
Genetic variability
Immune system
Nonhuman
Plasmodium vivax
Purifying selection
Pvron4 gene
Tandem repeat
Adolescent
Adult
Chemistry
Cluster analysis
Female
Genetic variation
Genetics
Haplotype
Human
Isolation and purification
Male
Middle aged
Molecular evolution
Parasitology
Phylogeny
Plasmodium vivax malaria
Sequence homology
Young adult
Haplotypes
Humans
Protozoan proteins
Functional restriction
Genetic diversity
Natural selection
Pvron4
Rhoptry
molecular
protozoan
vivax
dna
Dna
Evolution
Malaria
Sequence analysis
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22548
https://doi.org/10.1186/s12936-016-1563-4

Internet

https://repository.urosario.edu.co/handle/10336/22548
https://doi.org/10.1186/s12936-016-1563-4

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