Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-...

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Autores Principales: Pacheco Nieva, Yovana, Rodríguez-Jímenez, Mónica, Molano-González, Nicolas, Barahona-Correa, Julián, Monsalve, Diana M., Acosta-Ampudia, Yeny, Rojas, Manuel, Rodríguez, Yhojan, Saavedra, Juliana, Mantilla, Rubén D., Ramirez-Santana, Carolina, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: BioMed Central Ltd. 2017
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22483
https://doi.org/10.1186/s12967-017-1345-y
id ir-10336-22483
recordtype dspace
spelling ir-10336-224832022-05-02T12:37:16Z Cytokine and autoantibody clusters interaction in systemic lupus erythematosus Pacheco Nieva, Yovana Rodríguez-Jímenez, Mónica Molano-González, Nicolas Barahona-Correa, Julián Monsalve, Diana M. Acosta-Ampudia, Yeny Rojas, Manuel Rodríguez, Yhojan Saavedra, Juliana Mantilla, Rubén D. Ramirez-Santana, Carolina Anaya, Juan-Manuel Alpha interferon Autoantibody Biological marker Cytokine Cytokine antibody Double stranded dna antibody Granulocyte colony stimulating factor Phospholipid antibody Antinuclear antibody Autoantibody Cytokine Adult Article Controlled study Cross-sectional study Disease activity Female Human Major clinical study Personalized medicine Systemic lupus erythematosus Blood Cluster analysis Immunology Middle aged Systemic lupus erythematosus Young adult Adult Autoantibodies Cluster analysis Cross-sectional studies Cytokines Female Humans Middle aged Young adult Anti-dsdna antibodies Antiphospholipid antibodies Autoantibodies Cluster analysis Cytokines Interferon alpha Interleukin 12p40 Interleukin 8 Personalized medicine Subphenotypes Systemic lupus erythematosus Taxonomy systemic antinuclear Antibodies Lupus erythematosus Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s). 2017 2020-05-25T23:56:41Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14795876 https://repository.urosario.edu.co/handle/10336/22483 https://doi.org/10.1186/s12967-017-1345-y eng info:eu-repo/semantics/openAccess application/pdf BioMed Central Ltd. instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Alpha interferon
Autoantibody
Biological marker
Cytokine
Cytokine antibody
Double stranded dna antibody
Granulocyte colony stimulating factor
Phospholipid antibody
Antinuclear antibody
Autoantibody
Cytokine
Adult
Article
Controlled study
Cross-sectional study
Disease activity
Female
Human
Major clinical study
Personalized medicine
Systemic lupus erythematosus
Blood
Cluster analysis
Immunology
Middle aged
Systemic lupus erythematosus
Young adult
Adult
Autoantibodies
Cluster analysis
Cross-sectional studies
Cytokines
Female
Humans
Middle aged
Young adult
Anti-dsdna antibodies
Antiphospholipid antibodies
Autoantibodies
Cluster analysis
Cytokines
Interferon alpha
Interleukin 12p40
Interleukin 8
Personalized medicine
Subphenotypes
Systemic lupus erythematosus
Taxonomy
systemic
antinuclear
Antibodies
Lupus erythematosus
spellingShingle Alpha interferon
Autoantibody
Biological marker
Cytokine
Cytokine antibody
Double stranded dna antibody
Granulocyte colony stimulating factor
Phospholipid antibody
Antinuclear antibody
Autoantibody
Cytokine
Adult
Article
Controlled study
Cross-sectional study
Disease activity
Female
Human
Major clinical study
Personalized medicine
Systemic lupus erythematosus
Blood
Cluster analysis
Immunology
Middle aged
Systemic lupus erythematosus
Young adult
Adult
Autoantibodies
Cluster analysis
Cross-sectional studies
Cytokines
Female
Humans
Middle aged
Young adult
Anti-dsdna antibodies
Antiphospholipid antibodies
Autoantibodies
Cluster analysis
Cytokines
Interferon alpha
Interleukin 12p40
Interleukin 8
Personalized medicine
Subphenotypes
Systemic lupus erythematosus
Taxonomy
systemic
antinuclear
Antibodies
Lupus erythematosus
Pacheco Nieva, Yovana
Rodríguez-Jímenez, Mónica
Molano-González, Nicolas
Barahona-Correa, Julián
Monsalve, Diana M.
Acosta-Ampudia, Yeny
Rojas, Manuel
Rodríguez, Yhojan
Saavedra, Juliana
Mantilla, Rubén D.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
description Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s).
format Artículo (Article)
author Pacheco Nieva, Yovana
Rodríguez-Jímenez, Mónica
Molano-González, Nicolas
Barahona-Correa, Julián
Monsalve, Diana M.
Acosta-Ampudia, Yeny
Rojas, Manuel
Rodríguez, Yhojan
Saavedra, Juliana
Mantilla, Rubén D.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
author_facet Pacheco Nieva, Yovana
Rodríguez-Jímenez, Mónica
Molano-González, Nicolas
Barahona-Correa, Julián
Monsalve, Diana M.
Acosta-Ampudia, Yeny
Rojas, Manuel
Rodríguez, Yhojan
Saavedra, Juliana
Mantilla, Rubén D.
Ramirez-Santana, Carolina
Anaya, Juan-Manuel
author_sort Pacheco Nieva, Yovana
title Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
title_short Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
title_full Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
title_fullStr Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
title_full_unstemmed Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
title_sort cytokine and autoantibody clusters interaction in systemic lupus erythematosus
publisher BioMed Central Ltd.
publishDate 2017
url https://repository.urosario.edu.co/handle/10336/22483
https://doi.org/10.1186/s12967-017-1345-y
_version_ 1740172086126575616
score 12,131701