Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-...
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ir-10336-224832022-05-02T12:37:16Z Cytokine and autoantibody clusters interaction in systemic lupus erythematosus Pacheco Nieva, Yovana Rodríguez-Jímenez, Mónica Molano-González, Nicolas Barahona-Correa, Julián Monsalve, Diana M. Acosta-Ampudia, Yeny Rojas, Manuel Rodríguez, Yhojan Saavedra, Juliana Mantilla, Rubén D. Ramirez-Santana, Carolina Anaya, Juan-Manuel Alpha interferon Autoantibody Biological marker Cytokine Cytokine antibody Double stranded dna antibody Granulocyte colony stimulating factor Phospholipid antibody Antinuclear antibody Autoantibody Cytokine Adult Article Controlled study Cross-sectional study Disease activity Female Human Major clinical study Personalized medicine Systemic lupus erythematosus Blood Cluster analysis Immunology Middle aged Systemic lupus erythematosus Young adult Adult Autoantibodies Cluster analysis Cross-sectional studies Cytokines Female Humans Middle aged Young adult Anti-dsdna antibodies Antiphospholipid antibodies Autoantibodies Cluster analysis Cytokines Interferon alpha Interleukin 12p40 Interleukin 8 Personalized medicine Subphenotypes Systemic lupus erythematosus Taxonomy systemic antinuclear Antibodies Lupus erythematosus Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s). 2017 2020-05-25T23:56:41Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 14795876 https://repository.urosario.edu.co/handle/10336/22483 https://doi.org/10.1186/s12967-017-1345-y eng info:eu-repo/semantics/openAccess application/pdf BioMed Central Ltd. instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Alpha interferon Autoantibody Biological marker Cytokine Cytokine antibody Double stranded dna antibody Granulocyte colony stimulating factor Phospholipid antibody Antinuclear antibody Autoantibody Cytokine Adult Article Controlled study Cross-sectional study Disease activity Female Human Major clinical study Personalized medicine Systemic lupus erythematosus Blood Cluster analysis Immunology Middle aged Systemic lupus erythematosus Young adult Adult Autoantibodies Cluster analysis Cross-sectional studies Cytokines Female Humans Middle aged Young adult Anti-dsdna antibodies Antiphospholipid antibodies Autoantibodies Cluster analysis Cytokines Interferon alpha Interleukin 12p40 Interleukin 8 Personalized medicine Subphenotypes Systemic lupus erythematosus Taxonomy systemic antinuclear Antibodies Lupus erythematosus |
spellingShingle |
Alpha interferon Autoantibody Biological marker Cytokine Cytokine antibody Double stranded dna antibody Granulocyte colony stimulating factor Phospholipid antibody Antinuclear antibody Autoantibody Cytokine Adult Article Controlled study Cross-sectional study Disease activity Female Human Major clinical study Personalized medicine Systemic lupus erythematosus Blood Cluster analysis Immunology Middle aged Systemic lupus erythematosus Young adult Adult Autoantibodies Cluster analysis Cross-sectional studies Cytokines Female Humans Middle aged Young adult Anti-dsdna antibodies Antiphospholipid antibodies Autoantibodies Cluster analysis Cytokines Interferon alpha Interleukin 12p40 Interleukin 8 Personalized medicine Subphenotypes Systemic lupus erythematosus Taxonomy systemic antinuclear Antibodies Lupus erythematosus Pacheco Nieva, Yovana Rodríguez-Jímenez, Mónica Molano-González, Nicolas Barahona-Correa, Julián Monsalve, Diana M. Acosta-Ampudia, Yeny Rojas, Manuel Rodríguez, Yhojan Saavedra, Juliana Mantilla, Rubén D. Ramirez-Santana, Carolina Anaya, Juan-Manuel Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
description |
Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s). |
format |
Artículo (Article) |
author |
Pacheco Nieva, Yovana Rodríguez-Jímenez, Mónica Molano-González, Nicolas Barahona-Correa, Julián Monsalve, Diana M. Acosta-Ampudia, Yeny Rojas, Manuel Rodríguez, Yhojan Saavedra, Juliana Mantilla, Rubén D. Ramirez-Santana, Carolina Anaya, Juan-Manuel |
author_facet |
Pacheco Nieva, Yovana Rodríguez-Jímenez, Mónica Molano-González, Nicolas Barahona-Correa, Julián Monsalve, Diana M. Acosta-Ampudia, Yeny Rojas, Manuel Rodríguez, Yhojan Saavedra, Juliana Mantilla, Rubén D. Ramirez-Santana, Carolina Anaya, Juan-Manuel |
author_sort |
Pacheco Nieva, Yovana |
title |
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
title_short |
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
title_full |
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
title_fullStr |
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
title_full_unstemmed |
Cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
title_sort |
cytokine and autoantibody clusters interaction in systemic lupus erythematosus |
publisher |
BioMed Central Ltd. |
publishDate |
2017 |
url |
https://repository.urosario.edu.co/handle/10336/22483 https://doi.org/10.1186/s12967-017-1345-y |
_version_ |
1740172086126575616 |
score |
12,131701 |