Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

"Objectives Following up the systemic lupus erythematosus (SLE) genome-wide association studies (GWAS) identification of NMNAT2 at rs2022013, we fine-mapped its 150a €...kb flanking regions containing NMNAT2 and SMG7 in a 15a €...292 case-control multi-ancestry population and tested functions o...

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Autores Principales: Deng, Yun, Zhao, Jian, Sakurai, Daisuke, Sestak, Andrea L, Osadchiy, Vadim, Langefeld, Carl D, Kaufman, Kenneth M, Kelly, Jennifer A, James, Judith A, Petri, Michelle A, Bae, Sang-Cheol, Alarcón-Riquelme, Marta E, Alarcón, Graciela S, Anaya, Juan-Manuel, Criswell, Lindsey A, Freedman, Barry I, Kamen, Diane L, Gilkeson, Gary S, Jacob, Chaim O, Merrill, Joan T, Gaffney, Patrick M, Sivils, Kathy Moser, Niewold, Timothy B, Ramsey-Goldman, Rosalind, Reveille, John D, Scofield, R Hal, Stevens, Anne M, Boackle, Susan A, Vilá, Luis M, Sohn, I I Woong, Lee, Seung, Chang, Deh-Ming, Song, Yeong Wook, Vyse, Timothy J, Harley, John B, Brown, Elizabeth E, Edberg, Jeffrey C, Kimberly, Robert P, Cantor, Rita M, Hahn, Bevra H, Grossman, Jennifer M, Tsao, Betty P
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: BMJ Publishing Group 2016
Materias:
Rna
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22456
https://doi.org/10.1136/annrheumdis-2015-208441